[1-(tert-butyl-dimethyl-silanyloxymethyl)-1-(3,4-dimethoxy-benzyloxymethyl)-hex-5-en-2-ynyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[1-(tert-butyl-dimethyl-silanyloxymethyl)-1-(3,4-dimethoxy-benzyloxymethyl)-hex-5-en-2-ynyl]-carbamic acid tert-butyl ester
CAS No.:618440-75-8
Molecular Formula:C₂₈H₄₅NO₆Si
Molecular Weight:519.754
Hs Code.:

[1-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-1-(3,4-dimethoxy-benzyloxymethyl)-hex-5-en-2-ynyl]-carbamic acid <i>tert</i>-butyl ester

Synonyms:[1-(tert-butyl-dimethyl-silanyloxymethyl)-1-(3,4-dimethoxy-benzyloxymethyl)-hex-5-en-2-ynyl]-carbamic acid tert-butyl ester

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Chemical Property of [1-(tert-butyl-dimethyl-silanyloxymethyl)-1-(3,4-dimethoxy-benzyloxymethyl)-hex-5-en-2-ynyl]-carbamic acid tert-butyl ester

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Technology Process of [1-(tert-butyl-dimethyl-silanyloxymethyl)-1-(3,4-dimethoxy-benzyloxymethyl)-hex-5-en-2-ynyl]-carbamic acid tert-butyl ester

There total 1 articles about [1-(tert-butyl-dimethyl-silanyloxymethyl)-1-(3,4-dimethoxy-benzyloxymethyl)-hex-5-en-2-ynyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 106-95-6
allyl bromide

: 502183-37-1
(S)-[1-(tert-butyldimethylsilanyloxymethyl)-1-(3,4-dimethoxybenzyloxymethyl)prop-2-ynyl]carbamic acid tert-butyl ester

: 618440-75-8
[1-(tert-butyl-dimethyl-silanyloxymethyl)-1-(3,4-dimethoxy-benzyloxymethyl)-hex-5-en-2-ynyl]-carbamic acid tert-butyl ester

Guidance literature:: (S)-[1-(tert-butyldimethylsilanyloxymethyl)-1-(3,4-dimethoxybenzyloxymethyl)prop-2-ynyl]carbamic acid tert-butyl ester; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium diisopropyl amide; In tetrahydrofuran; at -50 ℃; for 0.25h;

allyl bromide; In tetrahydrofuran; at -50 ℃; for 6h;
DOI:10.1021/ol034984j

Reference yield:

: 618440-75-8
[1-(tert-butyl-dimethyl-silanyloxymethyl)-1-(3,4-dimethoxy-benzyloxymethyl)-hex-5-en-2-ynyl]-carbamic acid tert-butyl ester

: [1-(tert-butyl-dimethyl-silanyloxymethyl)-1-(3,4-dimethoxy-benzyloxymethyl)-hexyl]-carbamic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In benzene; for 12h; under 760 Torr;
DOI:10.1021/ol034984j

Reference yield:

: 618440-75-8
[1-(tert-butyl-dimethyl-silanyloxymethyl)-1-(3,4-dimethoxy-benzyloxymethyl)-hex-5-en-2-ynyl]-carbamic acid tert-butyl ester

: [1-(3,4-dimethoxy-benzyloxymethyl)-1-formyl-hexyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C / benzene / 12 h / 760 Torr

2: 100 mg / AcOH; HCl / H₂O; methanol / 2 h / 20 °C

3: Dess-Martin periodinane; NaHCO₃ / CH₂Cl₂

With hydrogenchloride; hydrogen; sodium hydrogencarbonate; Dess-Martin periodane; acetic acid; palladium on activated charcoal; In methanol; dichloromethane; water; benzene; 3: Dess-Martin oxidation;
DOI:10.1021/ol034984j