1-(2-bromo-4-(methoxymethoxy)phenyl)-2-(5-(triisopropylsilyloxy)pyridin-2-yl)propan-2-ol

Base Information

Chemical Name:1-(2-bromo-4-(methoxymethoxy)phenyl)-2-(5-(triisopropylsilyloxy)pyridin-2-yl)propan-2-ol
CAS No.:1380070-14-3
Molecular Formula:C₂₅H₃₈BrNO₄Si
Molecular Weight:524.571
Hs Code.:

Synonyms:1-(2-bromo-4-(methoxymethoxy)phenyl)-2-(5-(triisopropylsilyloxy)pyridin-2-yl)propan-2-ol

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Chemical Property of 1-(2-bromo-4-(methoxymethoxy)phenyl)-2-(5-(triisopropylsilyloxy)pyridin-2-yl)propan-2-ol

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Technology Process of 1-(2-bromo-4-(methoxymethoxy)phenyl)-2-(5-(triisopropylsilyloxy)pyridin-2-yl)propan-2-ol

There total 4 articles about 1-(2-bromo-4-(methoxymethoxy)phenyl)-2-(5-(triisopropylsilyloxy)pyridin-2-yl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1238394-83-6
2-bromo-5-((triisopropylsilyl)oxy)pyridine

: 1380070-13-2
1-(2-bromo-4-(methoxymethoxy)phenyl)propan-2-one

: 1380070-14-3
1-(2-bromo-4-(methoxymethoxy)phenyl)-2-(5-(triisopropylsilyloxy)pyridin-2-yl)propan-2-ol

Guidance literature:: 2-bromo-5-((triisopropylsilyl)oxy)pyridine; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 0.166667h;

1-(2-bromo-4-(methoxymethoxy)phenyl)propan-2-one; In diethyl ether; hexane; at -78 ℃; for 5h;

Reference yield:

: 66916-99-2
2-(2-bromo-4-(methoxy)phenyl)acetic acid

: 1380070-14-3
1-(2-bromo-4-(methoxymethoxy)phenyl)-2-(5-(triisopropylsilyloxy)pyridin-2-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: boron tribromide / dichloromethane / 3 h / Reflux

1.2: Cooling with ice

2.1: triethylamine; HATU / dichloromethane

3.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C

3.2: 2 h / 0 °C

4.1: diethyl ether / 1.5 h / 0 °C

5.1: n-butyllithium / hexane; diethyl ether / 0.17 h / -78 °C

5.2: 5 h / -78 °C

With n-butyllithium; boron tribromide; sodium hydride; triethylamine; HATU; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;

Reference yield:

: 1380070-11-0
2-(2-bromo-4-hydroxyphenyl)-N-methoxy-N-methylacetamide

: 1380070-14-3
1-(2-bromo-4-(methoxymethoxy)phenyl)-2-(5-(triisopropylsilyloxy)pyridin-2-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C

1.2: 2 h / 0 °C

2.1: diethyl ether / 1.5 h / 0 °C

3.1: n-butyllithium / hexane; diethyl ether / 0.17 h / -78 °C

3.2: 5 h / -78 °C

With n-butyllithium; sodium hydride; In tetrahydrofuran; diethyl ether; hexane;