2-fluoro-N-(6-(4-(4-fluorophenyl)-1-propyl-1H-imidazol-5-yl)imidazo[1,2-b]pyridazin-2-yl)isonicotinamide

Base Information

Chemical Name:2-fluoro-N-(6-(4-(4-fluorophenyl)-1-propyl-1H-imidazol-5-yl)imidazo[1,2-b]pyridazin-2-yl)isonicotinamide
CAS No.:1615724-11-2
Molecular Formula:C₂₄H₁₉F₂N₇O
Molecular Weight:459.458
Hs Code.:

Synonyms:2-fluoro-N-(6-(4-(4-fluorophenyl)-1-propyl-1H-imidazol-5-yl)imidazo[1,2-b]pyridazin-2-yl)isonicotinamide

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Chemical Property of 2-fluoro-N-(6-(4-(4-fluorophenyl)-1-propyl-1H-imidazol-5-yl)imidazo[1,2-b]pyridazin-2-yl)isonicotinamide

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Technology Process of 2-fluoro-N-(6-(4-(4-fluorophenyl)-1-propyl-1H-imidazol-5-yl)imidazo[1,2-b]pyridazin-2-yl)isonicotinamide

There total 6 articles about 2-fluoro-N-(6-(4-(4-fluorophenyl)-1-propyl-1H-imidazol-5-yl)imidazo[1,2-b]pyridazin-2-yl)isonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.9%

: 107-10-8,42939-71-9
propylamine

: 1615730-45-4
2-fluoro-N-(6-formylimidazo[1,2-b]pyridazin-2-yl)isonicotinamide

: 165806-95-1
1-((4-fluorophenyl)(isocyano)methylsulfonyl)-4-methylbenzene

: 1615724-11-2
2-fluoro-N-(6-(4-(4-fluorophenyl)-1-propyl-1H-imidazol-5-yl)imidazo[1,2-b]pyridazin-2-yl)isonicotinamide

Guidance literature:: propylamine; 2-fluoro-N-(6-formylimidazo[1,2-b]pyridazin-2-yl)isonicotinamide; With N,N-dimethyl-formamide; at 20 ℃;

1-((4-fluorophenyl)(isocyano)methylsulfonyl)-4-methylbenzene; With potassium carbonate;

Reference yield:

: 402-65-3
2-fluoropyridine-4-carboxylic acid

: 1615724-11-2
2-fluoro-N-(6-(4-(4-fluorophenyl)-1-propyl-1H-imidazol-5-yl)imidazo[1,2-b]pyridazin-2-yl)isonicotinamide

Guidance literature:: Multi-step reaction with 5 steps

1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4.5 h / 20 °C

2: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 100 °C / 7757.43 Torr / Autoclave

3: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 3.5 h / 20 °C / Cooling

4: Dess-Martin periodane / dimethyl sulfoxide / 1 h

5: N,N-dimethyl-formamide / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; diisobutylaluminium hydride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1615730-41-0
C₁₄H₁₀FN₅O₃

: 1615724-11-2
2-fluoro-N-(6-(4-(4-fluorophenyl)-1-propyl-1H-imidazol-5-yl)imidazo[1,2-b]pyridazin-2-yl)isonicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 3.5 h / 20 °C / Cooling

2: Dess-Martin periodane / dimethyl sulfoxide / 1 h

3: N,N-dimethyl-formamide / 20 °C

With diisobutylaluminium hydride; Dess-Martin periodane; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;