[4-{6-amino-5-[1-(5-fluoro-2-methoxyphenyl)ethoxy]pyridin-3-yl}-2-(methylsulfonyl)phenyl]methanol

Base Information

Chemical Name:[4-{6-amino-5-[1-(5-fluoro-2-methoxyphenyl)ethoxy]pyridin-3-yl}-2-(methylsulfonyl)phenyl]methanol
CAS No.:1346817-12-6
Molecular Formula:C₂₂H₂₃FN₂O₅S
Molecular Weight:446.499
Hs Code.:

Synonyms:[4-{6-amino-5-[1-(5-fluoro-2-methoxyphenyl)ethoxy]pyridin-3-yl}-2-(methylsulfonyl)phenyl]methanol

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Chemical Property of [4-{6-amino-5-[1-(5-fluoro-2-methoxyphenyl)ethoxy]pyridin-3-yl}-2-(methylsulfonyl)phenyl]methanol

Chemical Property:

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Technology Process of [4-{6-amino-5-[1-(5-fluoro-2-methoxyphenyl)ethoxy]pyridin-3-yl}-2-(methylsulfonyl)phenyl]methanol

There total 5 articles about [4-{6-amino-5-[1-(5-fluoro-2-methoxyphenyl)ethoxy]pyridin-3-yl}-2-(methylsulfonyl)phenyl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1346820-13-0
C₃₂H₃₉FN₂O₉S

: 1346817-12-6
[4-{6-amino-5-[1-(5-fluoro-2-methoxyphenyl)ethoxy]pyridin-3-yl}-2-(methylsulfonyl)phenyl]methanol

Guidance literature:: C₃₂H₃₉FN₂O₉S; With hydrogenchloride; In ethyl acetate; at 20 ℃;

With sodium hydrogencarbonate; In ethyl acetate; pH=8;

Reference yield:

: 3185-99-7
Methyl p-tolyl sulfone

: 1346817-12-6
[4-{6-amino-5-[1-(5-fluoro-2-methoxyphenyl)ethoxy]pyridin-3-yl}-2-(methylsulfonyl)phenyl]methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: bromine; iron / 0 - 20 °C

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 20 °C / Inert atmosphere; Reflux

3.1: hydrogenchloride / ethyl acetate / 20 °C

3.2: pH 8

With hydrogenchloride; bromine; iron; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; ethyl acetate;

Reference yield:

: 1346818-34-5
5-bromo-3-[1-(5-fluoro-2-methoxyphenyl)ethoxy]pyridin-2-ylamine

: 1346817-12-6
[4-{6-amino-5-[1-(5-fluoro-2-methoxyphenyl)ethoxy]pyridin-3-yl}-2-(methylsulfonyl)phenyl]methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap / N,N-dimethyl-formamide / 20 °C

2.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere

3.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 20 °C / Inert atmosphere; Reflux

4.1: hydrogenchloride / ethyl acetate / 20 °C

4.2: pH 8

With hydrogenchloride; dmap; potassium acetate; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; ethyl acetate; N,N-dimethyl-formamide;