5-bromo-3-(1-(5-fluoro-2-methoxyphenyl)ethoxy)-N,N-bis(tert-butoxycarbonyl)pyridin-2-ylamine

Base Information

Chemical Name:5-bromo-3-(1-(5-fluoro-2-methoxyphenyl)ethoxy)-N,N-bis(tert-butoxycarbonyl)pyridin-2-ylamine
CAS No.:1346819-78-0
Molecular Formula:C₂₄H₃₀BrFN₂O₆
Molecular Weight:541.414
Hs Code.:

Synonyms:5-bromo-3-(1-(5-fluoro-2-methoxyphenyl)ethoxy)-N,N-bis(tert-butoxycarbonyl)pyridin-2-ylamine

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Chemical Property of 5-bromo-3-(1-(5-fluoro-2-methoxyphenyl)ethoxy)-N,N-bis(tert-butoxycarbonyl)pyridin-2-ylamine

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Technology Process of 5-bromo-3-(1-(5-fluoro-2-methoxyphenyl)ethoxy)-N,N-bis(tert-butoxycarbonyl)pyridin-2-ylamine

There total 1 articles about 5-bromo-3-(1-(5-fluoro-2-methoxyphenyl)ethoxy)-N,N-bis(tert-butoxycarbonyl)pyridin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.7%

: 24424-99-5
di-tert-butyl dicarbonate

: 1346818-34-5
5-bromo-3-[1-(5-fluoro-2-methoxyphenyl)ethoxy]pyridin-2-ylamine

: 1346819-78-0
5-bromo-3-(1-(5-fluoro-2-methoxyphenyl)ethoxy)-N,N-bis(tert-butoxycarbonyl)pyridin-2-ylamine

Guidance literature:: With dmap; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 40.5%

: 1346819-78-0
5-bromo-3-(1-(5-fluoro-2-methoxyphenyl)ethoxy)-N,N-bis(tert-butoxycarbonyl)pyridin-2-ylamine

: 73183-34-3
bis(pinacol)diborane

: 1346819-81-5
3-(1-(5-fluoro-2-methoxyphenyl)ethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N,N-bis(tert-butoxycarbonyl)pyridin-2-amine

Guidance literature:: With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; at 80 ℃; for 3h; Inert atmosphere;

Reference yield:

: 1346819-78-0
5-bromo-3-(1-(5-fluoro-2-methoxyphenyl)ethoxy)-N,N-bis(tert-butoxycarbonyl)pyridin-2-ylamine

: 1346820-13-0
C₃₂H₃₉FN₂O₉S

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 20 °C / Inert atmosphere; Reflux

With potassium acetate; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water;