1-(4-(4-(3-(1H-indol-5-yl)-1H-pyrrolo [2,3-b]pyridin-5-yl)benzyl)-2-methylpiperazin-1-yl)ethananone

Base Information

Chemical Name:1-(4-(4-(3-(1H-indol-5-yl)-1H-pyrrolo [2,3-b]pyridin-5-yl)benzyl)-2-methylpiperazin-1-yl)ethananone
CAS No.:1351476-77-1
Molecular Formula:C₂₉H₂₉N₅O
Molecular Weight:463.582
Hs Code.:

Synonyms:1-(4-(4-(3-(1H-indol-5-yl)-1H-pyrrolo [2,3-b]pyridin-5-yl)benzyl)-2-methylpiperazin-1-yl)ethananone

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Chemical Property of 1-(4-(4-(3-(1H-indol-5-yl)-1H-pyrrolo [2,3-b]pyridin-5-yl)benzyl)-2-methylpiperazin-1-yl)ethananone

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Technology Process of 1-(4-(4-(3-(1H-indol-5-yl)-1H-pyrrolo [2,3-b]pyridin-5-yl)benzyl)-2-methylpiperazin-1-yl)ethananone

There total 9 articles about 1-(4-(4-(3-(1H-indol-5-yl)-1H-pyrrolo [2,3-b]pyridin-5-yl)benzyl)-2-methylpiperazin-1-yl)ethananone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₆H₃₅N₅O₃S

: 1351476-77-1
1-(4-(4-(3-(1H-indol-5-yl)-1H-pyrrolo [2,3-b]pyridin-5-yl)benzyl)-2-methylpiperazin-1-yl)ethananone

Guidance literature:: With sodium hydroxide; In methanol; at 50 ℃; for 1h;

Reference yield:

: 1351476-76-0
3-(1H-indol-5-yl)-5-(4-((3-methylpiperazin-1-yl)methyl)phenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine

: 108-24-7
acetic anhydride

: 1351476-77-1
1-(4-(4-(3-(1H-indol-5-yl)-1H-pyrrolo [2,3-b]pyridin-5-yl)benzyl)-2-methylpiperazin-1-yl)ethananone

Guidance literature:: 3-(1H-indol-5-yl)-5-(4-((3-methylpiperazin-1-yl)methyl)phenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine; acetic anhydride; With triethylamine; In methanol; dichloromethane; for 1h;

With sodium hydroxide; In methanol; at 50 ℃; for 1h;

Reference yield:

: 183208-35-7
5-bromo-1H-pyrrolo[2,3-b]pyridine

: 1351476-77-1
1-(4-(4-(3-(1H-indol-5-yl)-1H-pyrrolo [2,3-b]pyridin-5-yl)benzyl)-2-methylpiperazin-1-yl)ethananone

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-iodo-succinimide / acetone / 0.33 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C

2.2: 1.5 h / 0 °C

3.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 60 °C

4.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 0.17 h / 150 °C / Microwave irradiation; Inert atmosphere

5.1: dichloromethane / 2 h / 20 °C / Molecular sieve

6.1: trifluoroacetic acid / dichloromethane / 0.5 h

7.1: triethylamine / dichloromethane; methanol / 1 h

8.1: sodium hydroxide / methanol / 1 h / 50 °C

With N-iodo-succinimide; sodium hydride; sodium carbonate; triethylamine; trifluoroacetic acid; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; dichloromethane; acetone; acetonitrile; mineral oil;