tert-Butyl 4-[4-[5-[(acetylamino)methyl]-4,5-dihydro-3-isoxazolyl]phenyl]-3,6-dihydro-1(2H)-pyridinecarboxylate

Base Information

• Chemical Name: tert-Butyl 4-[4-[5-[(acetylamino)methyl]-4,5-dihydro-3-isoxazolyl]phenyl]-3,6-dihydro-1(2H)-pyridinecarboxylate
• CAS No.: 203633-87-8
• Molecular Formula: C₂₂H₂₉N₃O₄
• Molecular Weight: 399.49

Synonyms:tert-Butyl 4-[4-[5-[(acetylamino)methyl]-4,5-dihydro-3-isoxazolyl]phenyl]-3,6-dihydro-1(2H)-pyridinecarboxylate

Chemical Property of tert-Butyl 4-[4-[5-[(acetylamino)methyl]-4,5-dihydro-3-isoxazolyl]phenyl]-3,6-dihydro-1(2H)-pyridinecarboxylate

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Technology Process of tert-Butyl 4-[4-[5-[(acetylamino)methyl]-4,5-dihydro-3-isoxazolyl]phenyl]-3,6-dihydro-1(2H)-pyridinecarboxylate

There total 2 articles about tert-Butyl 4-[4-[5-[(acetylamino)methyl]-4,5-dihydro-3-isoxazolyl]phenyl]-3,6-dihydro-1(2H)-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (138647-49-1) + N-[[4,5-Dihydro-3-[4-(trimethylstannyl)phenyl]-5-isoxazolyl]methyl]-acetamide (203634-95-1) → tert-Butyl 4-[4-[5-[(acetylamino)methyl]-4,5-dihydro-3-isoxazolyl]phenyl]-3,6-dihydro-1(2H)-pyridinecarboxylate (203633-87-8)

Guidance literature:

With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; triphenyl-arsane; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 20h;

DOI:10.1021/jm020248u

Reference yield:

1-methyl-pyrrolidin-2-one (872-50-4,26138-58-9) + triphenyl-arsane (603-32-7) + 4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (138647-49-1) + N-[[4,5-Dihydro-3-[4-(trimethylstannyl)phenyl]-5-isoxazolyl]methyl]-acetamide (203634-95-1) → tert-Butyl 4-[4-[5-[(acetylamino)methyl]-4,5-dihydro-3-isoxazolyl]phenyl]-3,6-dihydro-1(2H)-pyridinecarboxylate (203633-87-8)

Guidance literature:

tris-(dibenzylideneacetone)dipalladium⁽⁰⁾;

Reference yield:

tert-Butyl 4-[4-[5-[(acetylamino)methyl]-4,5-dihydro-3-isoxazolyl]phenyl]-3,6-dihydro-1(2H)-pyridinecarboxylate (203633-87-8) → N-[[4,5-Dihydro-3-[4-(1,2,3,6-tetrahydropyridinyl) phenyl]-5-isoxazolyl]methyl]acetamide

Guidance literature:

With trifluoroacetic acid; In dichloromethane; potassium carbonate;

upstream raw materials:

4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

N-[[4,5-Dihydro-3-[4-(trimethylstannyl)phenyl]-5-isoxazolyl]methyl]-acetamide

1-methyl-pyrrolidin-2-one

triphenyl-arsane

Downstream raw materials:

(+/-)-N-[[4,5-dihydro-3-[4-[1,2,3,6-tetrahydropyridinyl]phenyl]-5-isoxazolyl]methyl]acetamide

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