Methanesulfonic acid (R)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-[(2S,3S,5R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-propyl ester

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Chemical Name:Methanesulfonic acid (R)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-[(2S,3S,5R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-propyl ester
CAS No.:246538-21-6
Molecular Formula:C₄₉H₄₉N₃O₁₁S
Molecular Weight:888.008
Hs Code.:

Methanesulfonic acid (R)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-[(2S,3S,5R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-propyl ester

Synonyms:Methanesulfonic acid (R)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-[(2S,3S,5R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-propyl ester

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Chemical Property of Methanesulfonic acid (R)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-[(2S,3S,5R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-propyl ester

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Technology Process of Methanesulfonic acid (R)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-[(2S,3S,5R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-propyl ester

There total 9 articles about Methanesulfonic acid (R)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-[(2S,3S,5R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52450-18-7
3'-amino-3'-deoxythymidine

: 246538-21-6
Methanesulfonic acid (R)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-[(2S,3S,5R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-propyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 87 percent / Na₂CO₃ / 1 h / 20 °C

2: 79 percent / DMSO; DCC; TFA / pyridine / 4 h / 20 °C

3: Zn / tetrahydrofuran / 20 h / 40 °C

4: AgNO₃; pyridine / 24 h / 50 °C

5: LiAlH₄ / tetrahydrofuran / 2 h / 0 °C

6: H₂ / 10 percent Pd/C / 14 h / 20 °C

7: Et₃N / tetrahydrofuran / 3 h / 20 °C

8: pyridine / 0.5 h / 20 °C

With pyridine; lithium aluminium tetrahydride; hydrogen; sodium carbonate; silver nitrate; dimethyl sulfoxide; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; zinc; palladium on activated charcoal; In tetrahydrofuran; pyridine; 1: Acylation / 2: Oxidation / 3: Condensation / 4: Etherification / 5: Reduction / 6: Hydrogenolysis / 7: Acylation / 8: Esterification;
DOI:10.1016/S0040-4039(99)01205-8

Reference yield:

: 30516-87-1,399024-19-2
3'-azido-2',3'-deoxythymidine

: 246538-21-6
Methanesulfonic acid (R)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-[(2S,3S,5R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-propyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 87 percent / H₂ / 10 percent Pd/C / 6 h / 20 °C

2: 87 percent / Na₂CO₃ / 1 h / 20 °C

3: 79 percent / DMSO; DCC; TFA / pyridine / 4 h / 20 °C

4: Zn / tetrahydrofuran / 20 h / 40 °C

5: AgNO₃; pyridine / 24 h / 50 °C

6: LiAlH₄ / tetrahydrofuran / 2 h / 0 °C

7: H₂ / 10 percent Pd/C / 14 h / 20 °C

8: Et₃N / tetrahydrofuran / 3 h / 20 °C

9: pyridine / 0.5 h / 20 °C

With pyridine; lithium aluminium tetrahydride; hydrogen; sodium carbonate; silver nitrate; dimethyl sulfoxide; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; zinc; palladium on activated charcoal; In tetrahydrofuran; pyridine; 1: Reduction / 2: Acylation / 3: Oxidation / 4: Condensation / 5: Etherification / 6: Reduction / 7: Hydrogenolysis / 8: Acylation / 9: Esterification;
DOI:10.1016/S0040-4039(99)01205-8

Reference yield:

: 246538-34-1
[(2S,3S,5R)-2-Formyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-carbamic acid benzyl ester

: 246538-21-6
Methanesulfonic acid (R)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-[(2S,3S,5R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-propyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: Zn / tetrahydrofuran / 20 h / 40 °C

2: AgNO₃; pyridine / 24 h / 50 °C

3: LiAlH₄ / tetrahydrofuran / 2 h / 0 °C

4: H₂ / 10 percent Pd/C / 14 h / 20 °C

5: Et₃N / tetrahydrofuran / 3 h / 20 °C

6: pyridine / 0.5 h / 20 °C

With pyridine; lithium aluminium tetrahydride; hydrogen; silver nitrate; triethylamine; zinc; palladium on activated charcoal; In tetrahydrofuran; 1: Condensation / 2: Etherification / 3: Reduction / 4: Hydrogenolysis / 5: Acylation / 6: Esterification;
DOI:10.1016/S0040-4039(99)01205-8