Carbamic acid, (4-methylenecyclohexyl)-, 1,1-dimethylethyl ester (9CI)

Base Information

• Chemical Name: Carbamic acid, (4-methylenecyclohexyl)-, 1,1-dimethylethyl ester (9CI)
• CAS No.: 725255-70-9
• Molecular Formula: C12H21 N O2
• Molecular Weight: 211.304
• Mol file: 725255-70-9.mol

Synonyms:Carbamicacid, (4-methylenecyclohexyl)-, 1,1-dimethylethyl ester (9CI)

Chemical Property of Carbamic acid, (4-methylenecyclohexyl)-, 1,1-dimethylethyl ester (9CI)

Chemical Property:

• PSA: 38.33000
• LogP: 3.40080

Purity/Quality:

98%,99%, ^*data from raw suppliers

tert-Butyl(4-Methylenecyclohexyl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, (4-methylenecyclohexyl)-, 1,1-dimethylethyl ester (9CI)

There total 2 articles about Carbamic acid, (4-methylenecyclohexyl)-, 1,1-dimethylethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

Methyltriphenylphosphonium bromide (1779-49-3) + N-(tert-butoxycarbonyl)-4-aminocyclohexanone (179321-49-4) → tert-butyl (4-methylenecyclohexyl)carbamate (725255-70-9)

Guidance literature:

Methyltriphenylphosphonium bromide; With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

N-(tert-butoxycarbonyl)-4-aminocyclohexanone; In tetrahydrofuran; at 0 ℃; for 1.33333h; Inert atmosphere;

Reference yield:

methyl-triphenylphosphonium iodide (2065-66-9) + N-(tert-butoxycarbonyl)-4-aminocyclohexanone (179321-49-4) → tert-butyl (4-methylenecyclohexyl)carbamate (725255-70-9)

Guidance literature:

methyl-triphenylphosphonium iodide; With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 3h;

N-(tert-butoxycarbonyl)-4-aminocyclohexanone; In tetrahydrofuran; at 0 - 20 ℃; for 10h;

Reference yield: 99.0%

tert-butyl (4-methylenecyclohexyl)carbamate (725255-70-9) → tert-butyl (4-methylcyclohex-3-en-1-yl)carbamate (291756-09-7)

Guidance literature:

With ammonia borane; C₁₆H₂₉Cl₂CoN₂P; In methanol; at 20 ℃; for 3h; regioselective reaction; Inert atmosphere; Schlenk technique; Glovebox;

DOI:10.1021/jacs.8b01815

upstream raw materials:

Methyltriphenylphosphonium bromide

N-(tert-butoxycarbonyl)-4-aminocyclohexanone

methyl-triphenylphosphonium iodide

Downstream raw materials:

C₁₇H₂₉NO₄

tert-butyl (4-methylcyclohex-3-en-1-yl)carbamate

spiro[2.5]octane-6-amine