tert-butyl(((3S,10R,13S,17R)-17-ethynyl-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)diphenylsilane

Base Information

Chemical Name:tert-butyl(((3S,10R,13S,17R)-17-ethynyl-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)diphenylsilane
CAS No.:1526915-63-8
Molecular Formula:C₃₇H₄₈OSi
Molecular Weight:536.873
Hs Code.:

tert-butyl(((3S,10R,13S,17R)-17-ethynyl-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)diphenylsilane

Synonyms:tert-butyl(((3S,10R,13S,17R)-17-ethynyl-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)diphenylsilane

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Chemical Property of tert-butyl(((3S,10R,13S,17R)-17-ethynyl-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)diphenylsilane

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Technology Process of tert-butyl(((3S,10R,13S,17R)-17-ethynyl-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)diphenylsilane

There total 8 articles about tert-butyl(((3S,10R,13S,17R)-17-ethynyl-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)diphenylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1526916-02-8
C₃₇H₄₈Br₂OSi

: 1526915-63-8
tert-butyl(((3S,10R,13S,17R)-17-ethynyl-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)diphenylsilane

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: (3S,10R,13S,17R)-17-ethynyl-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol

: 1526915-63-8
tert-butyl(((3S,10R,13S,17R)-17-ethynyl-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)diphenylsilane

Guidance literature:: tert-butylchlorodiphenylsilane; With 1H-imidazole; In dichloromethane; at 20 ℃; for 0.0833333h; Inert atmosphere; Schlenk technique;

(3S,10R,13S,17R)-17-ethynyl-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere; Schlenk technique;
DOI:10.1021/acs.orglett.8b02055

Reference yield:

: 1526930-28-8
1-((3S,10R,13S,17S)-3-((tert-butyldiphenylsilyl)oxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone

: 1526915-63-8
tert-butyl(((3S,10R,13S,17R)-17-ethynyl-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)diphenylsilane

Guidance literature:: Multi-step reaction with 5 steps

1.1: boron trifluoride diethyl etherate / methanol; toluene / 4 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

3.1: sodium periodate / tetrahydrofuran; water

4.1: triphenylphosphine / dichloromethane / 0.17 h / 0 °C

4.2: 0.33 h / 0 °C

5.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

With sodium periodate; lithium aluminium tetrahydride; n-butyllithium; boron trifluoride diethyl etherate; triphenylphosphine; In tetrahydrofuran; methanol; hexane; dichloromethane; water; toluene;