4-((3S,10R,13S,17S)-3-((tert-butyldiphenylsilyl)oxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-1H-1,2,3-triazole

Base Information

Chemical Name:4-((3S,10R,13S,17S)-3-((tert-butyldiphenylsilyl)oxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-1H-1,2,3-triazole
CAS No.:1526915-66-1
Molecular Formula:C₃₇H₄₉N₃OSi
Molecular Weight:579.901
Hs Code.:

4-((3S,10R,13S,17S)-3-((tert-butyldiphenylsilyl)oxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-1H-1,2,3-triazole

Synonyms:4-((3S,10R,13S,17S)-3-((tert-butyldiphenylsilyl)oxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-1H-1,2,3-triazole

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Chemical Property of 4-((3S,10R,13S,17S)-3-((tert-butyldiphenylsilyl)oxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-1H-1,2,3-triazole

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Technology Process of 4-((3S,10R,13S,17S)-3-((tert-butyldiphenylsilyl)oxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-1H-1,2,3-triazole

There total 8 articles about 4-((3S,10R,13S,17S)-3-((tert-butyldiphenylsilyl)oxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-1H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1526915-63-8
tert-butyl(((3S,10R,13S,17R)-17-ethynyl-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)diphenylsilane

: 1526915-66-1
4-((3S,10R,13S,17S)-3-((tert-butyldiphenylsilyl)oxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-1H-1,2,3-triazole

Guidance literature:: tert-butyl(((3S,10R,13S,17R)-17-ethynyl-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)diphenylsilane; With sodium azide; copper(ll) sulfate pentahydrate; acetic acid; sodium L-ascorbate; In 1,4-dioxane; at 20 ℃; for 18h;

With manganese(IV) oxide; In chloroform; for 20h; Reflux;

Reference yield:

: 1526930-28-8
1-((3S,10R,13S,17S)-3-((tert-butyldiphenylsilyl)oxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone

: 1526915-66-1
4-((3S,10R,13S,17S)-3-((tert-butyldiphenylsilyl)oxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-1H-1,2,3-triazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: boron trifluoride diethyl etherate / methanol; toluene / 4 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

3.1: sodium periodate / tetrahydrofuran; water

4.1: triphenylphosphine / dichloromethane / 0.17 h / 0 °C

4.2: 0.33 h / 0 °C

5.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

6.1: acetic acid; sodium L-ascorbate; copper(ll) sulfate pentahydrate; sodium azide / 1,4-dioxane / 18 h / 20 °C

6.2: 20 h / Reflux

With sodium periodate; lithium aluminium tetrahydride; n-butyllithium; sodium azide; copper(ll) sulfate pentahydrate; boron trifluoride diethyl etherate; acetic acid; sodium L-ascorbate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; water; toluene;

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1526915-66-1
4-((3S,10R,13S,17S)-3-((tert-butyldiphenylsilyl)oxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-1H-1,2,3-triazole

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1H-imidazole / dichloromethane / 4 h / 0 - 20 °C

2.1: boron trifluoride diethyl etherate / methanol; toluene / 4 h / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

4.1: sodium periodate / tetrahydrofuran; water

5.1: triphenylphosphine / dichloromethane / 0.17 h / 0 °C

5.2: 0.33 h / 0 °C

6.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

7.1: acetic acid; sodium L-ascorbate; copper(ll) sulfate pentahydrate; sodium azide / 1,4-dioxane / 18 h / 20 °C

7.2: 20 h / Reflux

With 1H-imidazole; sodium periodate; lithium aluminium tetrahydride; n-butyllithium; sodium azide; copper(ll) sulfate pentahydrate; boron trifluoride diethyl etherate; acetic acid; sodium L-ascorbate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; water; toluene;