(S)-2-(1-(4-(4-methoxy-2-methylphenoxy)phenyl)pyrrolidin-2-yl)acetonitrile

Base Information

Chemical Name:(S)-2-(1-(4-(4-methoxy-2-methylphenoxy)phenyl)pyrrolidin-2-yl)acetonitrile
CAS No.:1283147-35-2
Molecular Formula:C₂₀H₂₂N₂O₂
Molecular Weight:322.407
Hs Code.:

Synonyms:(S)-2-(1-(4-(4-methoxy-2-methylphenoxy)phenyl)pyrrolidin-2-yl)acetonitrile

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Chemical Property of (S)-2-(1-(4-(4-methoxy-2-methylphenoxy)phenyl)pyrrolidin-2-yl)acetonitrile

Chemical Property:

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Technology Process of (S)-2-(1-(4-(4-methoxy-2-methylphenoxy)phenyl)pyrrolidin-2-yl)acetonitrile

There total 6 articles about (S)-2-(1-(4-(4-methoxy-2-methylphenoxy)phenyl)pyrrolidin-2-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 1283147-14-7
(S)-2-(1-(4-hydroxyphenyl)pyrrolidin-2-yl)acetonitrile

: 208399-66-0
4-methoxy-2-methylphenyl boronic acid

: 1283147-35-2
(S)-2-(1-(4-(4-methoxy-2-methylphenoxy)phenyl)pyrrolidin-2-yl)acetonitrile

Guidance literature:: With triethylamine; copper diacetate; In dichloromethane; at 20 ℃; for 24h; Molecular sieve;

Reference yield:

: 23356-96-9
(S)-1-Pyrrolidin-2-yl-methanol

: 1283147-35-2
(S)-2-(1-(4-(4-methoxy-2-methylphenoxy)phenyl)pyrrolidin-2-yl)acetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / copper(l) iodide / isopropyl alcohol / 90 °C / Inert atmosphere

2: triethylamine / dichloromethane / 1 h / 0 °C

3: dimethyl sulfoxide / 4 h / 50 °C

4: hydrogen / palladium 10% on activated carbon / ethanol / 2 h

5: triethylamine / copper diacetate / dichloromethane / 24 h / 20 °C / Molecular sieve

With hydrogen; triethylamine; sodium hydroxide; copper(l) iodide; palladium 10% on activated carbon; copper diacetate; In ethanol; dichloromethane; dimethyl sulfoxide; isopropyl alcohol;

Reference yield:

: 19578-68-8
4-(4-benzyloxyphenyl) iodide

: 1283147-35-2
(S)-2-(1-(4-(4-methoxy-2-methylphenoxy)phenyl)pyrrolidin-2-yl)acetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / copper(l) iodide / isopropyl alcohol / 90 °C / Inert atmosphere

2: triethylamine / dichloromethane / 1 h / 0 °C

3: dimethyl sulfoxide / 4 h / 50 °C

4: hydrogen / palladium 10% on activated carbon / ethanol / 2 h

5: triethylamine / copper diacetate / dichloromethane / 24 h / 20 °C / Molecular sieve

With hydrogen; triethylamine; sodium hydroxide; copper(l) iodide; palladium 10% on activated carbon; copper diacetate; In ethanol; dichloromethane; dimethyl sulfoxide; isopropyl alcohol;