(7S,7aR)-7-hydroxy-2-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-hexahydro-pyrrolo[1,2-c]imidazol-3-one

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Chemical Name:(7S,7aR)-7-hydroxy-2-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-hexahydro-pyrrolo[1,2-c]imidazol-3-one
CAS No.:850003-09-7
Molecular Formula:C₁₇H₁₇N₃O₃
Molecular Weight:311.34
Hs Code.:

Synonyms:(7S,7aR)-7-hydroxy-2-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-hexahydro-pyrrolo[1,2-c]imidazol-3-one

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Chemical Property of (7S,7aR)-7-hydroxy-2-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-hexahydro-pyrrolo[1,2-c]imidazol-3-one

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Technology Process of (7S,7aR)-7-hydroxy-2-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-hexahydro-pyrrolo[1,2-c]imidazol-3-one

There total 5 articles about (7S,7aR)-7-hydroxy-2-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-hexahydro-pyrrolo[1,2-c]imidazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 850003-08-6
(7S,7aR)-7-(tert-butyl-dimethyl-silanyloxy)-2-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-hexahydro-pyrrolo[1,2-c]imidazol-3-one

: 850003-09-7
(7S,7aR)-7-hydroxy-2-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-hexahydro-pyrrolo[1,2-c]imidazol-3-one

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;

Reference yield:

: 850003-05-3
(2S,3S)-N-tert-butyloxycarbonyl-3-(tert-butyldimethylsilyloxy)-2-pyrrolidinecarboxylic acid methyl ester

: 850003-09-7
(7S,7aR)-7-hydroxy-2-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-hexahydro-pyrrolo[1,2-c]imidazol-3-one

Guidance literature:: Multi-step reaction with 6 steps

1: lithium triethylborohydride / tetrahydrofuran / 3.67 h / -78 - 20 °C

2: Dess-Martin periodane / 2 - 4 h / 0 - 20 °C

3: sodium tris(acetoxy)borohydride / acetic acid; 1,2-dichloro-ethane / 1 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane; toluene / 2 h / 0 - 20 °C

6: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 - 20 °C

With tetrabutyl ammonium fluoride; sodium tris(acetoxy)borohydride; lithium triethylborohydride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; acetic acid; 1,2-dichloro-ethane; toluene;

Reference yield:

: 184046-78-4
(2S,3S)-1-tert-butyl-2-methyl 3-hydroxypyrrolidine-1,2-dicarboxylate

: 850003-09-7
(7S,7aR)-7-hydroxy-2-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-hexahydro-pyrrolo[1,2-c]imidazol-3-one

Guidance literature:: Multi-step reaction with 7 steps

1: 1H-imidazole / dichloromethane / 20 °C

2: lithium triethylborohydride / tetrahydrofuran / 3.67 h / -78 - 20 °C

3: Dess-Martin periodane / 2 - 4 h / 0 - 20 °C

4: sodium tris(acetoxy)borohydride / acetic acid; 1,2-dichloro-ethane / 1 h / 20 °C

5: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

6: N-ethyl-N,N-diisopropylamine / dichloromethane; toluene / 2 h / 0 - 20 °C

7: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 - 20 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; sodium tris(acetoxy)borohydride; lithium triethylborohydride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; acetic acid; 1,2-dichloro-ethane; toluene;