(3R,5R)-benzyl 3-(2-(2-(2-(benzyloxy)-2-oxoethyl)-2-methylhydrazinyl)-2-oxoethyl)-5-(chloromethyl)isoxazolidine-2-carboxylate

Base Information

Chemical Name:(3R,5R)-benzyl 3-(2-(2-(2-(benzyloxy)-2-oxoethyl)-2-methylhydrazinyl)-2-oxoethyl)-5-(chloromethyl)isoxazolidine-2-carboxylate
CAS No.:1613376-40-1
Molecular Formula:C₂₄H₂₈ClN₃O₆
Molecular Weight:489.956
Hs Code.:

Synonyms:(3R,5R)-benzyl 3-(2-(2-(2-(benzyloxy)-2-oxoethyl)-2-methylhydrazinyl)-2-oxoethyl)-5-(chloromethyl)isoxazolidine-2-carboxylate

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Chemical Property of (3R,5R)-benzyl 3-(2-(2-(2-(benzyloxy)-2-oxoethyl)-2-methylhydrazinyl)-2-oxoethyl)-5-(chloromethyl)isoxazolidine-2-carboxylate

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Technology Process of (3R,5R)-benzyl 3-(2-(2-(2-(benzyloxy)-2-oxoethyl)-2-methylhydrazinyl)-2-oxoethyl)-5-(chloromethyl)isoxazolidine-2-carboxylate

There total 5 articles about (3R,5R)-benzyl 3-(2-(2-(2-(benzyloxy)-2-oxoethyl)-2-methylhydrazinyl)-2-oxoethyl)-5-(chloromethyl)isoxazolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1613376-35-4
(R)-benzyl (1-chloropent-4-en-2-yl)oxycarbamate

: 1613376-40-1
(3R,5R)-benzyl 3-(2-(2-(2-(benzyloxy)-2-oxoethyl)-2-methylhydrazinyl)-2-oxoethyl)-5-(chloromethyl)isoxazolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: ozone; oxygen / -78 °C

2: boron trifluoride diethyl etherate / dichloromethane / 24 h / -70 - -40 °C

3: ruthenium(III) chloride trihydrate; sodium periodate; water / chloroform; acetonitrile / 2 h / 20 °C

4: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 0.5 h

5: pyridine / 24 h

With pyridine; sodium periodate; oxalyl dichloride; ruthenium(III) chloride trihydrate; boron trifluoride diethyl etherate; water; oxygen; ozone; In dichloromethane; chloroform; N,N-dimethyl-formamide; acetonitrile; 2: |Sakurai Allylation;
DOI:10.1039/c4ob00537f

Reference yield:

: (5R)-2-benzyloxycarbonyl-5-chloromethyl-3-methoxyisoxazolidine

: 1613376-40-1
(3R,5R)-benzyl 3-(2-(2-(2-(benzyloxy)-2-oxoethyl)-2-methylhydrazinyl)-2-oxoethyl)-5-(chloromethyl)isoxazolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: boron trifluoride diethyl etherate / dichloromethane / 24 h / -70 - -40 °C

2: ruthenium(III) chloride trihydrate; sodium periodate; water / chloroform; acetonitrile / 2 h / 20 °C

3: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 0.5 h

4: pyridine / 24 h

With pyridine; sodium periodate; oxalyl dichloride; ruthenium(III) chloride trihydrate; boron trifluoride diethyl etherate; water; In dichloromethane; chloroform; N,N-dimethyl-formamide; acetonitrile; 1: |Sakurai Allylation;
DOI:10.1039/c4ob00537f

Reference yield:

: 1613376-37-6
(3S,5R)-3-allyl-2-benzyloxycarbonyl-5-chloromethylisoxazolidine

: 1613376-40-1
(3R,5R)-benzyl 3-(2-(2-(2-(benzyloxy)-2-oxoethyl)-2-methylhydrazinyl)-2-oxoethyl)-5-(chloromethyl)isoxazolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: ruthenium(III) chloride trihydrate; sodium periodate; water / chloroform; acetonitrile / 2 h / 20 °C

2: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 0.5 h

3: pyridine / 24 h

With pyridine; sodium periodate; oxalyl dichloride; ruthenium(III) chloride trihydrate; water; In dichloromethane; chloroform; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c4ob00537f