2,3-dichloro-N-(2-fluoro-4-iodophenyl)benzenesulfonamide

Base Information

• Chemical Name: 2,3-dichloro-N-(2-fluoro-4-iodophenyl)benzenesulfonamide
• CAS No.: 1279871-52-1
• Molecular Formula: C₁₂H₇Cl₂FINO₂S
• Molecular Weight: 446.068
• Mol file: 1279871-52-1.mol

Synonyms:2,3-dichloro-N-(2-fluoro-4-iodophenyl)benzenesulfonamide

Chemical Property of 2,3-dichloro-N-(2-fluoro-4-iodophenyl)benzenesulfonamide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2,3-dichloro-N-(2-fluoro-4-iodophenyl)benzenesulfonamide

There total 1 articles about 2,3-dichloro-N-(2-fluoro-4-iodophenyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-fluoro-5-iodoaniline (886362-82-9) + dichlorobenzenesulfonyl chloride (82417-45-6) → 2,3-dichloro-N-(2-fluoro-4-iodophenyl)benzenesulfonamide (1279871-52-1)

Guidance literature:

With pyridine; at 20 ℃; for 24h;

Reference yield: 40.0%

[7-amino-8-ethyl-6-(methylcarbamoyl)-5-oxo-5,8-dihydro-1,8-naphthyridin-2-yl]boronic acid (1204651-49-9) + 2,3-dichloro-N-(2-fluoro-4-iodophenyl)benzenesulfonamide (1279871-52-1) → 2-amino-7-(4-{[(2,3-dichlorophenyl)sulfonyl]amino}-3-fluorophenyl)-1-ethyl-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide (1314069-32-3)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydrogencarbonate; In water; N,N-dimethyl-formamide; at 85 ℃; for 5h; Inert atmosphere;

upstream raw materials:

2-fluoro-5-iodoaniline

dichlorobenzenesulfonyl chloride

Downstream raw materials:

2-amino-7-(4-{[(2,3-dichlorophenyl)sulfonyl]amino}-3-fluorophenyl)-1-ethyl-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide