10-[3-(cyclopropylsulfonylamino)-3-oxopropionyl]-11-(4-benzyloxy-2-chlorophenyl)-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-dibenzo[b,e][1,4]-diazepin-1-one

Base Information

Chemical Name:10-[3-(cyclopropylsulfonylamino)-3-oxopropionyl]-11-(4-benzyloxy-2-chlorophenyl)-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-dibenzo[b,e][1,4]-diazepin-1-one
CAS No.:1048334-87-7
Molecular Formula:C₃₄H₃₄ClN₃O₇S
Molecular Weight:664.179
Hs Code.:

10-[3-(cyclopropylsulfonylamino)-3-oxopropionyl]-11-(4-benzyloxy-2-chlorophenyl)-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-dibenzo[b,e][1,4]-diazepin-1-one

Synonyms:10-[3-(cyclopropylsulfonylamino)-3-oxopropionyl]-11-(4-benzyloxy-2-chlorophenyl)-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-dibenzo[b,e][1,4]-diazepin-1-one

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Chemical Property of 10-[3-(cyclopropylsulfonylamino)-3-oxopropionyl]-11-(4-benzyloxy-2-chlorophenyl)-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-dibenzo[b,e][1,4]-diazepin-1-one

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Technology Process of 10-[3-(cyclopropylsulfonylamino)-3-oxopropionyl]-11-(4-benzyloxy-2-chlorophenyl)-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-dibenzo[b,e][1,4]-diazepin-1-one

There total 2 articles about 10-[3-(cyclopropylsulfonylamino)-3-oxopropionyl]-11-(4-benzyloxy-2-chlorophenyl)-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-dibenzo[b,e][1,4]-diazepin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 1048041-43-5
11-(4-benzyloxy-2-chlorophenyl)-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-dibenzo[b,e][1,4]diazepin-1-one

: 1048339-84-9
3-(cyclopropanesulfonylamino)-3-oxo-propionic acid

: 1048334-87-7
10-[3-(cyclopropylsulfonylamino)-3-oxopropionyl]-11-(4-benzyloxy-2-chlorophenyl)-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-dibenzo[b,e][1,4]-diazepin-1-one

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 44.16h;

Reference yield:

: 1048339-81-6
C₇H₁₁NO₅S

: 1048334-87-7
10-[3-(cyclopropylsulfonylamino)-3-oxopropionyl]-11-(4-benzyloxy-2-chlorophenyl)-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-dibenzo[b,e][1,4]-diazepin-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide; water / tetrahydrofuran / 24 h / 20 °C

1.2: pH 6

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 44.16 h

With lithium hydroxide; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;