2-(7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepine-3-carbonyl)-3-p-tolyl-acrylonitrile

Base Information

• Chemical Name: 2-(7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepine-3-carbonyl)-3-p-tolyl-acrylonitrile
• CAS No.: 678171-14-7
• Molecular Formula: C₂₇H₂₀ClN₃O₂
• Molecular Weight: 453.928

Synonyms:2-(7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepine-3-carbonyl)-3-p-tolyl-acrylonitrile

Chemical Property of 2-(7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepine-3-carbonyl)-3-p-tolyl-acrylonitrile

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Technology Process of 2-(7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepine-3-carbonyl)-3-p-tolyl-acrylonitrile

There total 2 articles about 2-(7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepine-3-carbonyl)-3-p-tolyl-acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

4-methyl-benzaldehyde (104-87-0) + 3-[7'-chloro-1',3'-dihydro-1'-methyl-5'-phenyl-2'H-1',4'-benzodiazepin-2'-one-3'-yl]-3-oxopropanenitrile (678171-04-5) → 2-(7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepine-3-carbonyl)-3-p-tolyl-acrylonitrile (678171-14-7)

Guidance literature:

With potassium hydroxide; In ethanol; for 5h; Heating;

DOI:10.1016/S0928-0987(03)00162-3

Reference yield:

ethyl 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one-3-carboxylate (5606-57-5) → 2-(7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepine-3-carbonyl)-3-p-tolyl-acrylonitrile (678171-14-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / sodium hydride / benzene / 8 h / Heating

2: 68 percent / potassium hydroxide / ethanol / 5 h / Heating

With potassium hydroxide; sodium hydride; In ethanol; benzene;

DOI:10.1016/S0928-0987(03)00162-3

Reference yield: 59.0%

phenylhydrazine hydrochloride (59-88-1) + 2-(7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepine-3-carbonyl)-3-p-tolyl-acrylonitrile (678171-14-7) → 3-(7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-1-phenyl-5-p-tolyl-4,5-dihydro-1H-pyrazole-4-carbonitrile

Guidance literature:

With pyridine; In ethanol; for 6h; Heating;

DOI:10.1016/S0928-0987(03)00162-3

upstream raw materials:

4-methyl-benzaldehyde

3-[7'-chloro-1',3'-dihydro-1'-methyl-5'-phenyl-2'H-1',4'-benzodiazepin-2'-one-3'-yl]-3-oxopropanenitrile

ethyl 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one-3-carboxylate

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