1-(2-Benzofuranyl)-2,2,2-trifluoro-ethanone

Base Information

Chemical Name:1-(2-Benzofuranyl)-2,2,2-trifluoro-ethanone
CAS No.:75277-96-2
Molecular Formula:C10H5 F3 O2
Molecular Weight:214.144
Hs Code.:2932999099
DSSTox Substance ID:DTXSID10504862
Wikidata:Q82359628
Mol file:75277-96-2.mol

Synonyms:75277-96-2;1-(2-BENZOFURANYL)-2,2,2-TRIFLUORO-ETHANONE;1-(1-BENZOFURAN-2-YL)-2,2,2-TRIFLUOROETHANONE;1-(benzofuran-2-yl)-2,2,2-trifluoroethanone;DTXSID10504862;YOKGXQWCILDPON-UHFFFAOYSA-N;A19138;1-(1-Benzofuran-2-yl)-2,2,2-trifluoroethan-1-one

Suppliers and Price of 1-(2-Benzofuranyl)-2,2,2-trifluoro-ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
1-(2-BENZOFURANYL)-2,2,2-TRIFLUORO-ETHANONE 95.00%
5MG
$ 499.83

Total 7 raw suppliers

Chemical Property of 1-(2-Benzofuranyl)-2,2,2-trifluoro-ethanone

Chemical Property:

PSA：30.21000
LogP:3.17780
XLogP3:3.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:214.02416388
Heavy Atom Count:15
Complexity:262

Purity/Quality:

97% ^*data from raw suppliers

1-(2-BENZOFURANYL)-2,2,2-TRIFLUORO-ETHANONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C=C(O2)C(=O)C(F)(F)F

Technology Process of 1-(2-Benzofuranyl)-2,2,2-trifluoro-ethanone

There total 10 articles about 1-(2-Benzofuranyl)-2,2,2-trifluoro-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1187023-87-5
1-(benzofuran-2-yl)-2,2,2-trifluoroethan-1-ol

: 75277-96-2
1-(benzofuran-2-yl)-2,2,2-trifluoroethan-1-one

Guidance literature:: 1-(benzofuran-2-yl)-2,2,2-trifluoroethan-1-ol; With 4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate; In dichloromethane; at 20 ℃;

With 2,6-dimethylpyridine; In dichloromethane; at 20 ℃;
DOI:10.1002/ejoc.201500565

Reference yield: 78.0%

: 98437-24-2
benzofuran-2-boronic acid

: 181820-18-8
S-(tert-butyl)trifluorothioacetate

: 75277-96-2
1-(benzofuran-2-yl)-2,2,2-trifluoroethan-1-one

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(I) thiophene-2-carboxylate; trifuran-2-yl-phosphane; In tetrahydrofuran; at 30 ℃; for 18h; Sealed tube; Inert atmosphere;
DOI:10.1016/j.tetlet.2020.151780

Reference yield: 64.0%

: 496-41-3
Benzofuran-2-carboxylic acid

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 75277-96-2
1-(benzofuran-2-yl)-2,2,2-trifluoroethan-1-one

Guidance literature:: With dmap; cesium fluoride; trifluoroacetic anhydride; at 120 ℃; for 15h; Schlenk technique; Inert atmosphere;
DOI:10.1021/acs.orglett.1c01720