1,1-dimethylethyl ((1S)-2-{[3-({[2-chloro-4-(4-methyl-2-thienyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]amino}-1-methyl-2-oxoethyl)methylcarbamate

Base Information

Chemical Name:1,1-dimethylethyl ((1S)-2-{[3-({[2-chloro-4-(4-methyl-2-thienyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]amino}-1-methyl-2-oxoethyl)methylcarbamate
CAS No.:953391-88-3
Molecular Formula:C₂₇H₃₂ClN₃O₆S₂
Molecular Weight:594.153
Hs Code.:

1,1-dimethylethyl ((1S)-2-{[3-({[2-chloro-4-(4-methyl-2-thienyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]amino}-1-methyl-2-oxoethyl)methylcarbamate

Synonyms:1,1-dimethylethyl ((1S)-2-{[3-({[2-chloro-4-(4-methyl-2-thienyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]amino}-1-methyl-2-oxoethyl)methylcarbamate

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Chemical Property of 1,1-dimethylethyl ((1S)-2-{[3-({[2-chloro-4-(4-methyl-2-thienyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]amino}-1-methyl-2-oxoethyl)methylcarbamate

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Technology Process of 1,1-dimethylethyl ((1S)-2-{[3-({[2-chloro-4-(4-methyl-2-thienyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]amino}-1-methyl-2-oxoethyl)methylcarbamate

There total 5 articles about 1,1-dimethylethyl ((1S)-2-{[3-({[2-chloro-4-(4-methyl-2-thienyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]amino}-1-methyl-2-oxoethyl)methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 953391-80-5
1,1-dimethylethyl ((1S)-2-{[3-{[(4-bromo-2-chlorophenyl)sulfonyl]amino}-4-(methyloxy)phenyl]amino}-1-methyl-2-oxoethyl)methylcarbamate

: 162607-15-0
(4-methyl-2-thienyl)boronic acid

: 953391-88-3
1,1-dimethylethyl ((1S)-2-{[3-({[2-chloro-4-(4-methyl-2-thienyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]amino}-1-methyl-2-oxoethyl)methylcarbamate

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; water; at 120 ℃; for 0.333333h; Microwave irradiation;

Reference yield:

: 953391-74-7
N-[5-amino-2-(methyloxy)phenyl]-4-bromo-2-chlorobenzenesulfonamide

: 953391-88-3
1,1-dimethylethyl ((1S)-2-{[3-({[2-chloro-4-(4-methyl-2-thienyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]amino}-1-methyl-2-oxoethyl)methylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.33 h / 20 °C

1.2: 20 °C

2.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 0.33 h / 120 °C / Microwave irradiation

With sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

Reference yield:

: 953391-73-6
4-bromo-2-chloro-N-[2-(methyloxy)-5-nitrophenyl]benzenesulfonamide

: 953391-88-3
1,1-dimethylethyl ((1S)-2-{[3-({[2-chloro-4-(4-methyl-2-thienyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]amino}-1-methyl-2-oxoethyl)methylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium formate / 5 % platinum on carbon / methanol; water / 40 h / 20 °C

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.33 h / 20 °C

2.2: 20 °C

3.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 0.33 h / 120 °C / Microwave irradiation

With ammonium formate; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; 5 % platinum on carbon; In methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;