4-chloro-6-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrido[3,2-d]pyrimidine

Base Information

Chemical Name:4-chloro-6-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrido[3,2-d]pyrimidine
CAS No.:1400633-17-1
Molecular Formula:C₁₇H₁₃ClF₂N₄
Molecular Weight:346.767
Hs Code.:

Synonyms:4-chloro-6-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrido[3,2-d]pyrimidine

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Chemical Property of 4-chloro-6-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrido[3,2-d]pyrimidine

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Technology Process of 4-chloro-6-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrido[3,2-d]pyrimidine

There total 3 articles about 4-chloro-6-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrido[3,2-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1400633-16-0
4-chloro-6-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrido[3,2-d]pyrimidine

: 1400633-17-1
4-chloro-6-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrido[3,2-d]pyrimidine

Guidance literature:: With trichlorophosphate; at 100 ℃; for 2h;
DOI:10.1021/jm5006429

Reference yield:

: 171178-33-9
6-chloropyrido<3,2-d>pyrimidin-4(3H)-one

: 1400633-17-1
4-chloro-6-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrido[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol / 2 h / 150 °C / Microwave irradiation

2.1: trichlorophosphate / 2 h / 100 °C

2.2: pH ~ 8

With trichlorophosphate; In ethanol;

Reference yield:

: 1218935-59-1,1217630-38-0
(R)-(+)-2-(2,5-difluorophenyl)pyrrolidine

: 1400633-17-1
4-chloro-6-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrido[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol / 2 h / 150 °C / Microwave irradiation

2.1: trichlorophosphate / 2 h / 100 °C

2.2: pH ~ 8

With trichlorophosphate; In ethanol;