Technology Process of (2S,3S,5R)-1-benzyloxy-2-methyl-5-phenyl-3,5-pentanediol
There total 3 articles about (2S,3S,5R)-1-benzyloxy-2-methyl-5-phenyl-3,5-pentanediol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(1R,4S)-5-benzyloxy-1-hydroxy-4-methyl-1-phenyl-3-pentanone;
With
diethyl methoxy borane;
In
tetrahydrofuran;
at -78 ℃;
for 0.333333h;
Inert atmosphere;
With
sodium tetrahydroborate;
In
tetrahydrofuran;
at -78 ℃;
for 3h;
Inert atmosphere;
With
acetic acid;
In
tetrahydrofuran;
at -78 ℃;
Inert atmosphere;
DOI:10.1021/jo201021z
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: titanium tetrachloride / dichloromethane / -78 °C / Inert atmosphere
1.2: 0.5 h / -78 °C / Inert atmosphere
1.3: 0.5 h / -78 °C / Inert atmosphere
2.1: diethyl methoxy borane / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere
2.2: 3 h / -78 °C / Inert atmosphere
2.3: -78 °C / Inert atmosphere
With
diethyl methoxy borane; titanium tetrachloride;
In
tetrahydrofuran; dichloromethane;
1.3: Aldol condensation;
DOI:10.1021/jo201021z
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: titanium tetrachloride / dichloromethane / -78 °C / Inert atmosphere
1.2: 0.5 h / -78 °C / Inert atmosphere
1.3: 0.5 h / -78 °C / Inert atmosphere
2.1: diethyl methoxy borane / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere
2.2: 3 h / -78 °C / Inert atmosphere
2.3: -78 °C / Inert atmosphere
With
diethyl methoxy borane; titanium tetrachloride;
In
tetrahydrofuran; dichloromethane;
1.3: Aldol condensation;
DOI:10.1021/jo201021z
