benzyl (2S)-2-hydroxy-5-oxo-5-benzyloxypentanoate

Base Information

Chemical Name:benzyl (2S)-2-hydroxy-5-oxo-5-benzyloxypentanoate
CAS No.:212000-38-9
Molecular Formula:C₁₉H₂₀O₅
Molecular Weight:328.365
Hs Code.:

Synonyms:benzyl (2S)-2-hydroxy-5-oxo-5-benzyloxypentanoate

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Chemical Property of benzyl (2S)-2-hydroxy-5-oxo-5-benzyloxypentanoate

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Technology Process of benzyl (2S)-2-hydroxy-5-oxo-5-benzyloxypentanoate

There total 4 articles about benzyl (2S)-2-hydroxy-5-oxo-5-benzyloxypentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 21461-84-7
(2S)-tetrahydro-5-oxofuran-2-carboxylic acid

: 100-39-0
benzyl bromide

: 212000-38-9
benzyl (2S)-2-hydroxy-5-oxo-5-benzyloxypentanoate

Guidance literature:: (2S)-tetrahydro-5-oxofuran-2-carboxylic acid; With caesium carbonate; In water; for 18h; Heating / reflux;

With silica gel; In methanol; for 0.25h;

benzyl bromide; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 16h;

Reference yield:

: 100-39-0
benzyl bromide

: 156693-50-4
5-benzyloxycarbonyl-2-hydroxy-pentanedioic acid

: 212000-38-9
benzyl (2S)-2-hydroxy-5-oxo-5-benzyloxypentanoate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1021/ol301930h

Reference yield:

: 1676-73-9,25014-27-1
L-glutamic acid γ-benzyl ester

: 212000-38-9
benzyl (2S)-2-hydroxy-5-oxo-5-benzyloxypentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid; water; sodium nitrite / acetone / 60 °C / Flow reactor

2: caesium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

With sulfuric acid; water; caesium carbonate; sodium nitrite; In N,N-dimethyl-formamide; acetone;
DOI:10.1021/ol301930h