3'-O-(acetyloxymethyl)-5'-O-[(tert-butyl)dimethylsilyl]-N₆-(4-methoxytrityl)adenosin-2'-yl 2',3'-di-O-levylinoyl-N₆-(4-methoxytrityl)adenosin-5'-yl 3-acetyloxy-2,2-bis(ethoxycarbonyl)propyl phosphate

Base Information

• Chemical Name: 3'-O-(acetyloxymethyl)-5'-O-[(tert-butyl)dimethylsilyl]-N₆-(4-methoxytrityl)adenosin-2'-yl 2',3'-di-O-levylinoyl-N₆-(4-methoxytrityl)adenosin-5'-yl 3-acetyloxy-2,2-bis(ethoxycarbonyl)propyl phosphate
• CAS No.: 1259402-77-1
• Molecular Formula: C₉₀H₁₀₃N₁₀O₂₄PSi
• Molecular Weight: 1767.92

Synonyms:3'-O-(acetyloxymethyl)-5'-O-[(tert-butyl)dimethylsilyl]-N₆-(4-methoxytrityl)adenosin-2'-yl 2',3'-di-O-levylinoyl-N₆-(4-methoxytrityl)adenosin-5'-yl 3-acetyloxy-2,2-bis(ethoxycarbonyl)propyl phosphate

Chemical Property of 3'-O-(acetyloxymethyl)-5'-O-[(tert-butyl)dimethylsilyl]-N₆-(4-methoxytrityl)adenosin-2'-yl 2',3'-di-O-levylinoyl-N₆-(4-methoxytrityl)adenosin-5'-yl 3-acetyloxy-2,2-bis(ethoxycarbonyl)propyl phosphate

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Technology Process of 3'-O-(acetyloxymethyl)-5'-O-[(tert-butyl)dimethylsilyl]-N₆-(4-methoxytrityl)adenosin-2'-yl 2',3'-di-O-levylinoyl-N₆-(4-methoxytrityl)adenosin-5'-yl 3-acetyloxy-2,2-bis(ethoxycarbonyl)propyl phosphate

There total 1 articles about 3'-O-(acetyloxymethyl)-5'-O-[(tert-butyl)dimethylsilyl]-N₆-(4-methoxytrityl)adenosin-2'-yl 2',3'-di-O-levylinoyl-N₆-(4-methoxytrityl)adenosin-5'-yl 3-acetyloxy-2,2-bis(ethoxycarbonyl)propyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl ({[{[(2R,3R,4R,5R)-4-[(acetyloxy)methoxy]-5-({[(tert-butyl)(dimethyl)silyl]oxy}methyl)-2-(6-{[(4-methoxyphenyl)(diphenyl)methyl]amino}-9H-purin-9-yl)tetrahydrofuran-3-yl]oxy}({(2R,3R,4R,5R)-5-(6-{[(4-methoxyphenyl)(diphenyl)methyl]amino}-9H-purin-9-yl)-3,4-bis[(4-oxopentanoyl)oxy]tetrahydrofuran-2-yl}methoxy)phosphanyl]oxy}methyl)[(acetyloxy)methyl]propanedioate (1259402-76-0) → 3'-O-(acetyloxymethyl)-5'-O-[(tert-butyl)dimethylsilyl]-N6-(4-methoxytrityl)adenosin-2'-yl 2',3'-di-O-levylinoyl-N6-(4-methoxytrityl)adenosin-5'-yl 3-acetyloxy-2,2-bis(ethoxycarbonyl)propyl phosphate (1259402-77-1)

Guidance literature:

With 2,6-dimethylpyridine; water; iodine; In tetrahydrofuran;

DOI:10.1002/cbdv.201000288

Reference yield: 93.0%

3'-O-(acetyloxymethyl)-5'-O-[(tert-butyl)dimethylsilyl]-N6-(4-methoxytrityl)adenosin-2'-yl 2',3'-di-O-levylinoyl-N6-(4-methoxytrityl)adenosin-5'-yl 3-acetyloxy-2,2-bis(ethoxycarbonyl)propyl phosphate (1259402-77-1) → 3-acetyloxy-2,2-bis(ethoxycarbonyl)propyl 3'-O-(acetyloxymethyl)-N6-(4-methoxytrityl)adenosin-2'-yl 2',3'-di-O-levylinoyl-N6-(4-methoxytrityl)adenosin-5'-yl phosphate (1259402-78-2)

Guidance literature:

With triethylamine tris(hydrogen fluoride); In tetrahydrofuran; at 20 ℃; for 72h;

DOI:10.1002/cbdv.201000288

upstream raw materials:

diethyl ({[{[(2R,3R,4R,5R)-4-[(acetyloxy)methoxy]-5-({[(tert-butyl)(dimethyl)silyl]oxy}methyl)-2-(6-{[(4-methoxyphenyl)(diphenyl)methyl]amino}-9H-purin-9-yl)tetrahydrofuran-3-yl]oxy}({(2R,3R,4R,5R)-5-(6-{[(4-methoxyphenyl)(diphenyl)methyl]amino}-9H-purin-9-yl)-3,4-bis[(4-oxopentanoyl)oxy]tetrahydrofuran-2-yl}methoxy)phosphanyl]oxy}methyl)[(acetyloxy)methyl]propanedioate

Downstream raw materials:

3-acetyloxy-2,2-bis(ethoxycarbonyl)propyl 3'-O-(acetyloxymethyl)-N₆-(4-methoxytrityl)adenosin-2'-yl 2',3'-di-O-levylinoyl-N₆-(4-methoxytrityl)adenosin-5'-yl phosphate

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