2-{-4-[1-(4-cyclopropylmethoxy-2-methoxy-phenyl)-piperidin-4-yl]-phenyl}-N-ethyl-propionamide

Base Information

Chemical Name:2-{-4-[1-(4-cyclopropylmethoxy-2-methoxy-phenyl)-piperidin-4-yl]-phenyl}-N-ethyl-propionamide
CAS No.:1441255-02-2
Molecular Formula:C₂₇H₃₆N₂O₃
Molecular Weight:436.594
Hs Code.:

Synonyms:2-{-4-[1-(4-cyclopropylmethoxy-2-methoxy-phenyl)-piperidin-4-yl]-phenyl}-N-ethyl-propionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-{-4-[1-(4-cyclopropylmethoxy-2-methoxy-phenyl)-piperidin-4-yl]-phenyl}-N-ethyl-propionamide

Chemical Property:

Purity/Quality:

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Technology Process of 2-{-4-[1-(4-cyclopropylmethoxy-2-methoxy-phenyl)-piperidin-4-yl]-phenyl}-N-ethyl-propionamide

There total 5 articles about 2-{-4-[1-(4-cyclopropylmethoxy-2-methoxy-phenyl)-piperidin-4-yl]-phenyl}-N-ethyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1353776-76-7
1-Bromo-4-cyclopropylmethoxy-2-methoxy-benzene

: 1441257-09-5
N-ethyl-2-(4-piperidin-4-yl-phenyl)-propionamide

: 1441255-02-2
2-{-4-[1-(4-cyclopropylmethoxy-2-methoxy-phenyl)-piperidin-4-yl]-phenyl}-N-ethyl-propionamide

Guidance literature:: With copper(l) iodide; potassium carbonate; L-proline; In dimethyl sulfoxide; at 90 - 100 ℃; for 264h; Inert atmosphere;

Reference yield:

: 1364766-12-0
N-ethyl-2-(4-iodo-phenyl)-propionamide

: 1441255-02-2
2-{-4-[1-(4-cyclopropylmethoxy-2-methoxy-phenyl)-piperidin-4-yl]-phenyl}-N-ethyl-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / methanol; 1,4-dioxane / 48 h / Inert atmosphere; Reflux

2: hydrogen; platinum(IV) oxide / ethanol / 6 h / 20 °C / 3750.38 Torr

3: copper(l) iodide; L-proline; potassium carbonate / dimethyl sulfoxide / 264 h / 90 - 100 °C / Inert atmosphere

With platinum(IV) oxide; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; hydrogen; sodium carbonate; potassium carbonate; L-proline; In 1,4-dioxane; methanol; ethanol; dimethyl sulfoxide;

Reference yield:

: 41073-25-0
2-(4-iodo-phenyl)-propionic acid methyl ester

: 1441255-02-2
2-{-4-[1-(4-cyclopropylmethoxy-2-methoxy-phenyl)-piperidin-4-yl]-phenyl}-N-ethyl-propionamide

Guidance literature:: Multi-step reaction with 5 steps

1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 2 h / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole / dichloromethane / 20 h / 0 - 20 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / methanol; 1,4-dioxane / 48 h / Inert atmosphere; Reflux

4: hydrogen; platinum(IV) oxide / ethanol / 6 h / 20 °C / 3750.38 Torr

5: copper(l) iodide; L-proline; potassium carbonate / dimethyl sulfoxide / 264 h / 90 - 100 °C / Inert atmosphere

With platinum(IV) oxide; copper(l) iodide; 1-hydroxy-7-aza-benzotriazole; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; lithium hydroxide monohydrate; water; hydrogen; sodium carbonate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; L-proline; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; dimethyl sulfoxide;