4-<1,3,4,5,8,8a-hexahydro-7-(phenylsulfonyl)-4a(2H)-naphthalenyl>morpholine

Base Information

• Chemical Name: 4-<1,3,4,5,8,8a-hexahydro-7-(phenylsulfonyl)-4a(2H)-naphthalenyl>morpholine
• CAS No.: 109802-91-7
• Molecular Formula: C₂₀H₂₇NO₃S
• Molecular Weight: 361.505
• Mol file: 109802-91-7.mol

Synonyms:4-<1,3,4,5,8,8a-hexahydro-7-(phenylsulfonyl)-4a(2H)-naphthalenyl>morpholine

Chemical Property of 4-<1,3,4,5,8,8a-hexahydro-7-(phenylsulfonyl)-4a(2H)-naphthalenyl>morpholine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-<1,3,4,5,8,8a-hexahydro-7-(phenylsulfonyl)-4a(2H)-naphthalenyl>morpholine

There total 5 articles about 4-<1,3,4,5,8,8a-hexahydro-7-(phenylsulfonyl)-4a(2H)-naphthalenyl>morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-cyclohexen-1-ylmorpholine (670-80-4) + (E)-1,2-bis(phenylsulfonyl)-2-butene (122521-49-7) → 4-<1,3,4,5,8,8a-hexahydro-7-(phenylsulfonyl)-4a(2H)-naphthalenyl>morpholine (109802-91-7)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In benzene; for 2h; Ambient temperature;

DOI:10.1021/jo00278a049

Reference yield: 70.0%

4-cyclohexen-1-ylmorpholine (670-80-4) + 2-Benzenesulfonyl-1,3-butadiene (109802-71-3) → 4-<1,3,4,5,8,8a-hexahydro-7-(phenylsulfonyl)-4a(2H)-naphthalenyl>morpholine (109802-91-7)

Guidance literature:

In dichloromethane; for 2h; Ambient temperature;

DOI:10.1021/ja00255a027

Reference yield:

3-(phenylsulfonyl)-4-(chloromercuri)but-1-ene (102815-47-4) → 4-<1,3,4,5,8,8a-hexahydro-7-(phenylsulfonyl)-4a(2H)-naphthalenyl>morpholine (109802-91-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / aq. NaOH (2 M) / diethyl ether / 0.33 h / Ambient temperature

2: 70 percent / CH₂Cl₂ / 2 h / Ambient temperature

With sodium hydroxide; In diethyl ether; dichloromethane;

DOI:10.1021/ja00255a027

upstream raw materials:

4-cyclohexen-1-ylmorpholine

2-Benzenesulfonyl-1,3-butadiene

(E)-1,2-bis(phenylsulfonyl)-2-butene

3-(phenylsulfonyl)-4-(chloromercuri)but-1-ene