2-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)oxy)thiazole-5-carbonitrile

Base Information

Chemical Name:2-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)oxy)thiazole-5-carbonitrile
CAS No.:1416860-74-6
Molecular Formula:C₁₉H₁₁F₄N₇O₂S
Molecular Weight:477.402
Hs Code.:

Synonyms:2-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)oxy)thiazole-5-carbonitrile

Suppliers and Price of 2-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)oxy)thiazole-5-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)oxy)thiazole-5-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)oxy)thiazole-5-carbonitrile

There total 7 articles about 2-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)oxy)thiazole-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.9%

: 1416861-06-7
6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-ol

: 51640-36-9
2-chloro-1,3-thiazole-5-carbonitrile

: 1416860-74-6
2-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)oxy)thiazole-5-carbonitrile

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 20 ℃; for 4h; Inert atmosphere;

Reference yield:

: 624-28-2
2,5-dibromopyridine

: 1416860-74-6
2-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)oxy)thiazole-5-carbonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: copper / dimethyl sulfoxide / 1 h / 20 °C

1.2: 15 h / 20 °C

2.1: n-butyllithium / hexane; diethyl ether / 0.25 h / -70 °C

2.2: 2 h / -70 - 20 °C

3.1: diethyl ether / 2 h / 0 - 20 °C

4.1: n-butyllithium / hexane; diethyl ether / 0.5 h / -78 °C

4.2: 0.67 h / -78 - 20 °C

5.1: Oxone / water; acetone / 18 h / 20 °C

6.1: dimethyl sulfoxide / 70 °C / Inert atmosphere

7.1: potassium carbonate / dimethyl sulfoxide / 4 h / 20 °C / Inert atmosphere

With Oxone; n-butyllithium; copper; potassium carbonate; In diethyl ether; hexane; water; dimethyl sulfoxide; acetone;

Reference yield:

: 294181-95-6
2-(5-bromopyridine-2-yl)-2,2-difluoroacetic acid ethyl ester

: 1416860-74-6
2-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)oxy)thiazole-5-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / hexane; diethyl ether / 0.25 h / -70 °C

1.2: 2 h / -70 - 20 °C

2.1: diethyl ether / 2 h / 0 - 20 °C

3.1: n-butyllithium / hexane; diethyl ether / 0.5 h / -78 °C

3.2: 0.67 h / -78 - 20 °C

4.1: Oxone / water; acetone / 18 h / 20 °C

5.1: dimethyl sulfoxide / 70 °C / Inert atmosphere

6.1: potassium carbonate / dimethyl sulfoxide / 4 h / 20 °C / Inert atmosphere

With Oxone; n-butyllithium; potassium carbonate; In diethyl ether; hexane; water; dimethyl sulfoxide; acetone;