(S)-4'-((5-((1-(4-cyclopropylphenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid

Base Information

Chemical Name:(S)-4'-((5-((1-(4-cyclopropylphenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid
CAS No.:1415255-62-7
Molecular Formula:C₃₆H₃₄N₂O₃
Molecular Weight:542.678
Hs Code.:

Synonyms:(S)-4'-((5-((1-(4-cyclopropylphenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid

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Chemical Property of (S)-4'-((5-((1-(4-cyclopropylphenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid

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Technology Process of (S)-4'-((5-((1-(4-cyclopropylphenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid

There total 8 articles about (S)-4'-((5-((1-(4-cyclopropylphenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1338259-06-5
(S)-4'-((5-((1-(4-bromophenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid

: 411235-57-9
cyclopropylboronic acid

: 1415255-62-7
(S)-4'-((5-((1-(4-cyclopropylphenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid

Guidance literature:: With potassium phosphate; palladium diacetate; tricyclohexylphosphine; In water; toluene; at 100 ℃; for 1h; Microwave irradiation;

Reference yield:

: 114772-36-0
tert-butyl 4'-methyl-2-biphenylcarboxylate

: 1415255-62-7
(S)-4'-((5-((1-(4-cyclopropylphenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 2 h / 100 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C

2.2: 1 h / 20 °C

3.1: sodium hydroxide; ethanol / 2 h / 100 °C

4.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.08 h

4.2: 0.5 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

6.1: palladium diacetate; potassium phosphate; tricyclohexylphosphine / water; toluene / 1 h / 100 °C / Microwave irradiation

With potassium phosphate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); ethanol; palladium diacetate; sodium hydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; tricyclohexylphosphine; In tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 1220018-34-7
ethyl 1-[(2'-{[(tert-butyl)oxy]carbonyl}-4-biphenyl)methyl]-2,3-dimethyl-1H-indole-5-carboxylate

: 1415255-62-7
(S)-4'-((5-((1-(4-cyclopropylphenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; ethanol / 2 h / 100 °C

2.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.08 h

2.2: 0.5 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4.1: palladium diacetate; potassium phosphate; tricyclohexylphosphine / water; toluene / 1 h / 100 °C / Microwave irradiation

With potassium phosphate; ethanol; palladium diacetate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; tricyclohexylphosphine; In dichloromethane; water; N,N-dimethyl-formamide; toluene;