N-(2-oxopropyl)-N-phenylacetamide

Base Information

• Chemical Name: N-(2-oxopropyl)-N-phenylacetamide
• CAS No.: 64450-18-6
• Molecular Formula: C11H13 N O2
• Molecular Weight: 191.23
• NSC Number: 174197
• DSSTox Substance ID: DTXSID90306129
• Nikkaji Number: J2.602.141C
• Wikidata: Q82053061
• Mol file: 64450-18-6.mol

Synonyms:N-(2-oxopropyl)-N-phenylacetamide;64450-18-6;NSC174197;SCHEMBL11557648;DTXSID90306129;ADAL1012918;NSC-174197

Chemical Property of N-(2-oxopropyl)-N-phenylacetamide

Chemical Property:

• Vapor Pressure: 0.000891mmHg at 25°C
• Boiling Point: 304.1°Cat760mmHg
• Flash Point: 128.2°C
• Density: 1.117g/cm³
• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 191.094628657
• Heavy Atom Count: 14
• Complexity: 219

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)CN(C1=CC=CC=C1)C(=O)C

Technology Process of N-(2-oxopropyl)-N-phenylacetamide

There total 6 articles about N-(2-oxopropyl)-N-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

N-(2-methylprop-2-ene-1-yl)-N-phenylacetamide (102860-03-7) → N-(2-oxopropyl)-N-phenyl-acetamide (64450-18-6)

Guidance literature:

With sodium periodate; RuO₂/BaTi₄O₉; In phosphate buffer; ethyl acetate; at 20 ℃; pH=6.88;

DOI:10.1055/s-2007-992378

Reference yield: 58.0%

vinyl acetate (108-05-4,9003-20-7) + carbon monoxide (201230-82-2) + aniline (62-53-3) → N-(2-oxopropyl)-N-phenyl-acetamide (64450-18-6)

Guidance literature:

With acetylacetonatodicarbonylrhodium(l); hydrogen; 1,2-bis-(diphenylphosphino)ethane; In dichloromethane; toluene; at 90 - 120 ℃; for 40h; under 45004.5 Torr; Reagent/catalyst; regioselective reaction; Inert atmosphere; Schlenk technique; Autoclave;

DOI:10.1021/acs.joc.5b02851

Reference yield:

N-allyl-N-phenylacetamide (55487-54-2) → N-(2-oxopropyl)-N-phenyl-acetamide (64450-18-6) + N-(3-Oxo-propyl)-N-phenyl-acetamide (138196-42-6)

Guidance literature:

With water; oxygen; copper dichloride; palladium dichloride; In tetrahydrofuran; at 50 ℃; Yield given;

DOI:10.1039/c39910001559

upstream raw materials:

acetic anhydride

N-Phenylglycine

N-allyl-N-phenylacetamide

N-phenyl-N-prop-2-ynylamine

Downstream raw materials:

N-[2-(4-nitro-phenylhydrazono)-propyl]-acetanilide

(4-nitro-anilino)-acetone

Refernces

• 1、 Okumoto, Hiroshi,Ohtsuka, Kazuhiro,Banjoya, Shinji. "Use of the composite material RuO2/BaTi4O9 as an environmentally benign solid catalyst for the oxidative cleavage of olefins". . p. 3201 - 3205. Retrieved 2008/09/20.