Technology Process of rel-(4aS,8aS)-8a-<(benzyloxy)methyl>-1,4,4a,5,6,7,8,8a-octahydro-2(3H)-naphthalenone
There total 2 articles about rel-(4aS,8aS)-8a-<(benzyloxy)methyl>-1,4,4a,5,6,7,8,8a-octahydro-2(3H)-naphthalenone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) NaH, 2.) n-BuLi / 1.) THF, DMF, 2.) THF, Et2O, -78 deg C, 50 min
2: 1.) n-butyllithium, 2.) copper(I)bromide-dimethyl sulfide complex 3.) chlorotrimethylsilane / 2.) isopropylmagnesium chloride / 1.) hexane, -78 deg C, 10 min, 2.) diisopropyl sulfide, THF, -78 deg C, 15 min, 3.) THF, diisopropyl sulfide, hexane, -78 deg C, 15 min, - 40 deg C, 10 min, 0 deg C, 2 min
With
n-butyllithium; chloro-trimethyl-silane; copper(I) bromide dimethylsulfide complex; sodium hydride;
isopropylmagnesium chloride;
DOI:10.1021/ja00250a029
- Guidance literature:
-
With
n-butyllithium; chloro-trimethyl-silane; copper(I) bromide dimethylsulfide complex;
isopropylmagnesium chloride;
Yield given. Multistep reaction;
1.) hexane, -78 deg C, 10 min, 2.) diisopropyl sulfide, THF, -78 deg C, 15 min, 3.) THF, diisopropyl sulfide, hexane, -78 deg C, 15 min, - 40 deg C, 10 min, 0 deg C, 2 min;
DOI:10.1021/ja00250a029
