(1'S,3R)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]octan-3-ol

Base Information

• Chemical Name: (1'S,3R)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]octan-3-ol
• CAS No.: 952651-94-4
• Molecular Formula: C₃₁H₄₂O₃Si
• Molecular Weight: 490.758
• Mol file: 952651-94-4.mol

Synonyms:(1'S,3R)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]octan-3-ol

Chemical Property of (1'S,3R)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]octan-3-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of (1'S,3R)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]octan-3-ol

There total 1 articles about (1'S,3R)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]octan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1'S)-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]propionaldehyde + n-pentylmagnesium bromide (693-25-4) → (1'S,3R)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]octan-3-ol (952651-94-4) + (1'S,3S)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]octan-3-ol

Guidance literature:

With magnesium bromide; In diethyl ether; dichloromethane; at -78 ℃; for 0.333333h;

DOI:10.1021/ol071382h

Reference yield: 95.0%

(1'S,3R)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]octan-3-ol (952651-94-4) → (+)-(S)-(1-methoxy-2,2,2-triphenylethyl)dimethylsilane (952652-04-9) + (R)-1-octane-1,3-diol (120727-18-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at 0 ℃; for 0.666667h;

DOI:10.1021/ol071382h

Reference yield:

(1'S,3R)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]octan-3-ol (952651-94-4) → (S)-1-{2-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]phenyl}ethanone

Guidance literature:

Multi-step reaction with 2 steps

1.1: 95 percent / LiAlH₄ / diethyl ether; tetrahydrofuran / 0.67 h / 0 °C

2.1: Br₂ / CH₂Cl₂ / -78 - 23 °C

2.2: 86 percent / triethylamine; DMAP / CH₂Cl₂ / 1 h / 0 - 23 °C

With lithium aluminium tetrahydride; bromine; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1021/ol071382h

upstream raw materials:

n-pentylmagnesium bromide

Downstream raw materials:

(+)-(S)-(1-methoxy-2,2,2-triphenylethyl)dimethylsilane

(R)-1-octane-1,3-diol