N-{9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-methoxy-8-oxo-8,9-dihydro-7H-purin-2-yl}-2-phenoxy-acetamide

Base Information

Chemical Name:N-{9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-methoxy-8-oxo-8,9-dihydro-7H-purin-2-yl}-2-phenoxy-acetamide
CAS No.:174361-97-8
Molecular Formula:C₃₁H₄₉N₅O₇Si₂
Molecular Weight:659.93
Hs Code.:

N-{9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-methoxy-8-oxo-8,9-dihydro-7H-purin-2-yl}-2-phenoxy-acetamide

Synonyms:N-{9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-methoxy-8-oxo-8,9-dihydro-7H-purin-2-yl}-2-phenoxy-acetamide

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Chemical Property of N-{9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-methoxy-8-oxo-8,9-dihydro-7H-purin-2-yl}-2-phenoxy-acetamide

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Technology Process of N-{9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-methoxy-8-oxo-8,9-dihydro-7H-purin-2-yl}-2-phenoxy-acetamide

There total 6 articles about N-{9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-methoxy-8-oxo-8,9-dihydro-7H-purin-2-yl}-2-phenoxy-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 174361-96-7
N-{8-Benzyloxy-9-[(2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-methoxy-9H-purin-2-yl}-2-phenoxy-acetamide

: 174361-97-8
N-{9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-methoxy-8-oxo-8,9-dihydro-7H-purin-2-yl}-2-phenoxy-acetamide

Guidance literature:: With hydrogen; palladium on activated charcoal; at 24 ℃; for 1h; under 2585.7 Torr;
DOI:10.1016/0040-4039(95)02069-1

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 174361-97-8
N-{9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-methoxy-8-oxo-8,9-dihydro-7H-purin-2-yl}-2-phenoxy-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: imidazole / dimethylformamide / 4 h / 24 °C

2: pyridine / 16 h / 24 °C

3: 54.5 percent / DEAD, PH₃P / dioxane / 16 h / 24 °C

4: 96 percent / hydrogen / 10percent Pd/C / 1 h / 24 °C / 2585.7 Torr

With pyridine; 1H-imidazole; hydrogen; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/0040-4039(95)02069-1

Reference yield:

: 96964-90-8
8-(benzyloxy)-2'-deoxyguanosine

: 174361-97-8
N-{9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-methoxy-8-oxo-8,9-dihydro-7H-purin-2-yl}-2-phenoxy-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: imidazole / dimethylformamide / 4 h / 24 °C

2: pyridine / 16 h / 24 °C

3: 54.5 percent / DEAD, PH₃P / dioxane / 16 h / 24 °C

4: 96 percent / hydrogen / 10percent Pd/C / 1 h / 24 °C / 2585.7 Torr

With pyridine; 1H-imidazole; hydrogen; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/0040-4039(95)02069-1