C₁₈H₂₇IO₄

Base Information

• Chemical Name: C₁₈H₂₇IO₄
• CAS No.: 1350818-16-4
• Molecular Formula: C₁₈H₂₇IO₄
• Molecular Weight: 434.314
• Mol file: 1350818-16-4.mol

Synonyms:C₁₈H₂₇IO₄

Chemical Property of C₁₈H₂₇IO₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₂₇IO₄

There total 5 articles about C₁₈H₂₇IO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

C25H34O7S (1350818-15-3) → C18H27IO4 (1350818-16-4)

Guidance literature:

With sodium iodide; In acetone; for 24h; Reflux;

DOI:10.1016/j.tetlet.2011.09.134

Reference yield:

C6H12O2 (955044-11-8) → C18H27IO4 (1350818-16-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 4 h / 0 - 20 °C

1.2: 2 h / 20 °C

2.1: triethylamine / dichloromethane / 8 h / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 0 - 20 °C

4.1: sodium iodide / acetone / 24 h / Reflux

With triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium iodide; In dichloromethane; acetone; 1.1: Prins reaction;

DOI:10.1016/j.tetlet.2011.09.134

Reference yield:

(2S,3R,4S,6S)-2-(2-(benzyloxy)ethyl)-6-(hydroxymethyl)-3-methyltetrahydro-2H-pyran-4-ol (1350818-12-0) → C18H27IO4 (1350818-16-4)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 8 h / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 0 - 20 °C

3: sodium iodide / acetone / 24 h / Reflux

With triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; In dichloromethane; acetone;

DOI:10.1016/j.tetlet.2011.09.134

upstream raw materials:

C₂₅H₃₄O₇S

C₆H₁₂O₂

(2S,3R,4S,6S)-2-(2-(benzyloxy)ethyl)-6-(hydroxymethyl)-3-methyltetrahydro-2H-pyran-4-ol

((2S,4S,5R,6S)-6-(2-(benzyloxy)ethyl)-4-hydroxy-5-methyltetrahydro-2H-pyran-2-yl)methyl-4-methylbenzenesulfonate

Downstream raw materials:

(2S,3S)-2-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]hex-5-en-3-ol

C₁₈H₂₆O₄

C₂₄H₃₂O₆

C₂₂H₂₈O₅