1-(4-(methylthio)phenyl)-3-trifluoromethyl-5-(4-fluoro-2-hydroxyphenyl)pyrazole

Base Information

Chemical Name:1-(4-(methylthio)phenyl)-3-trifluoromethyl-5-(4-fluoro-2-hydroxyphenyl)pyrazole
CAS No.:1338216-25-3
Molecular Formula:C₁₇H₁₂F₄N₂OS
Molecular Weight:368.355
Hs Code.:

Synonyms:1-(4-(methylthio)phenyl)-3-trifluoromethyl-5-(4-fluoro-2-hydroxyphenyl)pyrazole

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Chemical Property of 1-(4-(methylthio)phenyl)-3-trifluoromethyl-5-(4-fluoro-2-hydroxyphenyl)pyrazole

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Technology Process of 1-(4-(methylthio)phenyl)-3-trifluoromethyl-5-(4-fluoro-2-hydroxyphenyl)pyrazole

There total 3 articles about 1-(4-(methylthio)phenyl)-3-trifluoromethyl-5-(4-fluoro-2-hydroxyphenyl)pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1338216-20-8
1-(4-(methylthio)phenyl)-3-trifluoromethyl-5-(4-fluoro-2-methoxyphenyl)pyrazole

: 1338216-25-3
1-(4-(methylthio)phenyl)-3-trifluoromethyl-5-(4-fluoro-2-hydroxyphenyl)pyrazole

Guidance literature:: With hydrogen bromide; cetyltributylphosphonium bromide; at 115 ℃; for 5h;
DOI:10.1016/j.bmcl.2011.08.053

Reference yield:

: 1338216-04-8
C₁₁H₈F₄O₃

: 1338216-25-3
1-(4-(methylthio)phenyl)-3-trifluoromethyl-5-(4-fluoro-2-hydroxyphenyl)pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 24 h / Reflux

2: hydrogen bromide; cetyltributylphosphonium bromide / 5 h / 115 °C

With hydrogen bromide; cetyltributylphosphonium bromide; In ethanol;
DOI:10.1016/j.bmcl.2011.08.053

Reference yield:

: 51788-80-8
1-(4-fluoro-2-methoxy-phenyl)-ethanone

: 1338216-25-3
1-(4-(methylthio)phenyl)-3-trifluoromethyl-5-(4-fluoro-2-hydroxyphenyl)pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium methylate / methanol; tert-butyl methyl ether / 0.08 h

1.2: 24 h / Reflux

2.1: ethanol / 24 h / Reflux

3.1: hydrogen bromide; cetyltributylphosphonium bromide / 5 h / 115 °C

With hydrogen bromide; sodium methylate; cetyltributylphosphonium bromide; In methanol; ethanol; tert-butyl methyl ether; 1.1: Claisen condensation / 1.2: Claisen condensation;
DOI:10.1016/j.bmcl.2011.08.053