ethyl 4-{3-[3-(3-benzhydryl-6-oxo-1,6-dihydropyridazin-1-yl)propyl]phenoxy}butanoate

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Chemical Name:ethyl 4-{3-[3-(3-benzhydryl-6-oxo-1,6-dihydropyridazin-1-yl)propyl]phenoxy}butanoate
CAS No.:1034019-38-9
Molecular Formula:C₃₂H₃₄N₂O₄
Molecular Weight:510.633
Hs Code.:

Synonyms:ethyl 4-{3-[3-(3-benzhydryl-6-oxo-1,6-dihydropyridazin-1-yl)propyl]phenoxy}butanoate

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Chemical Property of ethyl 4-{3-[3-(3-benzhydryl-6-oxo-1,6-dihydropyridazin-1-yl)propyl]phenoxy}butanoate

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Technology Process of ethyl 4-{3-[3-(3-benzhydryl-6-oxo-1,6-dihydropyridazin-1-yl)propyl]phenoxy}butanoate

There total 12 articles about ethyl 4-{3-[3-(3-benzhydryl-6-oxo-1,6-dihydropyridazin-1-yl)propyl]phenoxy}butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1034021-65-2
C₁₅H₂₁IO₃

: 172937-96-1
6-benzhydryl-2,3-dihydropyridazin-3-one

: 1034019-38-9
ethyl 4-{3-[3-(3-benzhydryl-6-oxo-1,6-dihydropyridazin-1-yl)propyl]phenoxy}butanoate

Guidance literature:: With lithium hydride; In N,N-dimethyl-formamide; at 25 ℃; for 4h;
DOI:10.1021/op3001492

Reference yield:

: 1034021-26-5
ethyl 4-{3-[3-(mesyloxy)propyl]phenoxy}butanoate

: 172937-96-1
6-benzhydryl-2,3-dihydropyridazin-3-one

: 1034019-38-9
ethyl 4-{3-[3-(3-benzhydryl-6-oxo-1,6-dihydropyridazin-1-yl)propyl]phenoxy}butanoate

Guidance literature:: With sodium hydroxide; In ethanol; at 50 - 65 ℃; for 40h; Large scale;
DOI:10.1021/op3001492

Reference yield:

: 621-54-5
3-(3-hydroxyphenyl)-propanoic acid

: 1034019-38-9
ethyl 4-{3-[3-(3-benzhydryl-6-oxo-1,6-dihydropyridazin-1-yl)propyl]phenoxy}butanoate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene; tetrahydrofuran / 2 h / 70 °C

2: potassium carbonate / N,N-dimethyl-formamide / 85 - 90 °C / Large scale

3: triethylamine / toluene / 10 °C / Large scale

4: sodium hydroxide / ethanol / 40 h / 50 - 65 °C / Large scale

With potassium carbonate; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/op3001492