N₂-(3-(allyloxy)-4-(4-chloro-1H-imidazol-1-yl)phenyl)-N₄-(but-3-enyl)-N₄-methyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine

Base Information

• Chemical Name: N₂-(3-(allyloxy)-4-(4-chloro-1H-imidazol-1-yl)phenyl)-N₄-(but-3-enyl)-N₄-methyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine
• CAS No.: 1356010-27-9
• Molecular Formula: C₃₀H₃₁ClN₆O
• Molecular Weight: 527.069

Synonyms:N₂-(3-(allyloxy)-4-(4-chloro-1H-imidazol-1-yl)phenyl)-N₄-(but-3-enyl)-N₄-methyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine

Chemical Property of N₂-(3-(allyloxy)-4-(4-chloro-1H-imidazol-1-yl)phenyl)-N₄-(but-3-enyl)-N₄-methyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine

Chemical Property:

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Technology Process of N₂-(3-(allyloxy)-4-(4-chloro-1H-imidazol-1-yl)phenyl)-N₄-(but-3-enyl)-N₄-methyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine

There total 14 articles about N₂-(3-(allyloxy)-4-(4-chloro-1H-imidazol-1-yl)phenyl)-N₄-(but-3-enyl)-N₄-methyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.34%

4-(4-chloro-1H-imidazol-1-yl)-3-allyloxyaniline (1356009-05-6) + N-(but-3-enyl)-2-chloro-N-methyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine (1356009-72-7) → N2-(3-(allyloxy)-4-(4-chloro-1H-imidazol-1-yl)phenyl)-N4-(but-3-enyl)-N4-methyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine (1356010-27-9)

Guidance literature:

at 150 ℃; for 0.333333h;

Reference yield:

cyclopent-1-en-1-ylbenzene (825-54-7) → N2-(3-(allyloxy)-4-(4-chloro-1H-imidazol-1-yl)phenyl)-N4-(but-3-enyl)-N4-methyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine (1356010-27-9)

Guidance literature:

Multi-step reaction with 8 steps

1.1: formic acid; dihydrogen peroxide / 4 h / 20 - 40 °C

2.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -78 °C

2.2: 3 h / 25 °C

3.1: potassium hydroxide / water / 20 °C

4.1: hydrogenchloride; water / 1 h / Reflux

5.1: ammonia / water / 5 h / Heating

6.1: trichlorophosphate / 1 h / 110 °C / microwave irradiation

7.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 18 h / 20 °C

8.1: 0.33 h / 150 °C

With hydrogenchloride; n-butyllithium; formic acid; ammonia; water; dihydrogen peroxide; diisopropylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; trichlorophosphate; In tetrahydrofuran; hexanes; water; acetonitrile;

Reference yield:

phenylmagnesium bromide (100-58-3) → N2-(3-(allyloxy)-4-(4-chloro-1H-imidazol-1-yl)phenyl)-N4-(but-3-enyl)-N4-methyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine (1356010-27-9)

Guidance literature:

Multi-step reaction with 9 steps

1.1: diethyl ether; tetrahydrofuran / 2.5 h / 0 °C / Reflux

2.1: formic acid; dihydrogen peroxide / 4 h / 20 - 40 °C

3.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -78 °C

3.2: 3 h / 25 °C

4.1: potassium hydroxide / water / 20 °C

5.1: hydrogenchloride; water / 1 h / Reflux

6.1: ammonia / water / 5 h / Heating

7.1: trichlorophosphate / 1 h / 110 °C / microwave irradiation

8.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 18 h / 20 °C

9.1: 0.33 h / 150 °C

With hydrogenchloride; n-butyllithium; formic acid; ammonia; water; dihydrogen peroxide; diisopropylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; trichlorophosphate; In tetrahydrofuran; hexanes; diethyl ether; water; acetonitrile;

upstream raw materials:

cyclopentanone

phenylmagnesium bromide

2-chloro-5-nitroanisole

2-Phenylcyclopentanone

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