5'-O-dimethoxytrityl-N-benzoyldeoxycytidine 3'-p-nitrophenylsuccinate

Base Information

• Chemical Name: 5'-O-dimethoxytrityl-N-benzoyldeoxycytidine 3'-p-nitrophenylsuccinate
• CAS No.: 107905-16-8
• Molecular Formula: C₄₇H₄₂N₄O₁₂
• Molecular Weight: 854.87
• Mol file: 107905-16-8.mol

Synonyms:5'-O-dimethoxytrityl-N-benzoyldeoxycytidine 3'-p-nitrophenylsuccinate

Chemical Property of 5'-O-dimethoxytrityl-N-benzoyldeoxycytidine 3'-p-nitrophenylsuccinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5'-O-dimethoxytrityl-N-benzoyldeoxycytidine 3'-p-nitrophenylsuccinate

There total 2 articles about 5'-O-dimethoxytrityl-N-benzoyldeoxycytidine 3'-p-nitrophenylsuccinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + 5'-O-dimethoxytrityl-N-benzoyldeoxycytidine 3'-succinate (74405-44-0) → 1,3-Dicyclohexylurea (2387-23-7) + 5'-O-dimethoxytrityl-N-benzoyldeoxycytidine 3'-p-nitrophenylsuccinate (107905-16-8)

Guidance literature:

With dicyclohexyl-carbodiimide; In 1,4-dioxane; pyridine; at 20 ℃; for 2h;

DOI:10.1016/0040-4020(84)85107-8

Reference yield:

4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine (67219-55-0) → 5'-O-dimethoxytrityl-N-benzoyldeoxycytidine 3'-p-nitrophenylsuccinate (107905-16-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / N,N-dimethylaminopyridine / pyridine / 12 h / 20 °C

2: dicyclohexylcarbodiimide / pyridine; dioxane / 2 h / 20 °C

With dmap; dicyclohexyl-carbodiimide; In 1,4-dioxane; pyridine;

DOI:10.1016/0040-4020(84)85107-8

upstream raw materials:

4-nitro-phenol

5'-O-dimethoxytrityl-N-benzoyldeoxycytidine 3'-succinate

4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine