Technology Process of 11-hydroxy-9-undecynoic acid
There total 1 articles about 11-hydroxy-9-undecynoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 89 percent / LiAlH4 / tetrahydrofuran / 2 h / -10 - 15 °C
2: 86 percent / HBr / 1 h / 100 - 110 °C
3: 1.) LiNH2 / 1.) liq. NH3, from -50 deg C to -40 deg C, 0.5 h, 2.) THF, liq. NH3, a) -33 deg C, 1 h, b) RT, 4 h
4: NaI / dimethylsulfoxide / 1.5 h / 100 - 125 °C
5: 10percent aq. NaOH / 5 h / 90 - 100 °C
With
sodium hydroxide; lithium aluminium tetrahydride; lithium amide; hydrogen bromide; sodium iodide;
In
tetrahydrofuran; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 92 percent / PBr3
2: 95 percent / Me3SiCl
3: 96 percent / KI / dimethylformamide / 15 h / 50 °C
4: 50 percent / EtMgBr; CuCl / tetrahydrofuran / 15 h / 20 °C
With
chloro-trimethyl-silane; ethylmagnesium bromide; phosphorus tribromide; potassium iodide; copper(l) chloride;
In
tetrahydrofuran; N,N-dimethyl-formamide;
4: Grignard coupling reaction;
DOI:10.1016/S0040-4039(02)02640-0
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 92 percent / PBr3
2: 95 percent / Me3SiCl
3: 96 percent / KI / dimethylformamide / 15 h / 50 °C
4: 51 percent / EtMgBr; CuCl / tetrahydrofuran / 15 h / 20 °C
With
chloro-trimethyl-silane; ethylmagnesium bromide; phosphorus tribromide; potassium iodide; copper(l) chloride;
In
tetrahydrofuran; N,N-dimethyl-formamide;
4: Grignard coupling reaction;
DOI:10.1016/S0040-4039(02)02640-0
