821-57-8

Basic information

• Product Name: 7-CHLOROHEPTANOIC ACID
• Synonyms: 7-chloro-enanticaci;7-chloro-heptanoicaci;chlorenanthicacid;RARECHEM AL BO 2373;7-CHLOROHEPTANOIC ACID;7-chloroenanthic acid;Heptanoic acid,7-chloro-
• CAS NO: 821-57-8
• Molecular Formula: C₇H₁₃ClO₂
• Molecular Weight: 164.63
• Mol File: 821-57-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 269.8 °C at 760 mmHg
• Flash Point: 117 °C
• Appearance: /
• Density: 1.096 g/cm³
• Vapor Pressure: 0.00201mmHg at 25°C
• Refractive Index: 1.457
• PKA: 4.76±0.10(Predicted)
• CAS DataBase Reference: 7-CHLOROHEPTANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 7-CHLOROHEPTANOIC ACID(821-57-8)
• EPA Substance Registry System: 7-CHLOROHEPTANOIC ACID(821-57-8)

Safety Data

• Hazardous Substances Data: 821-57-8(Hazardous Substances Data)

Usage

General Description

7-Chloroheptanoic Acid is a chemical compound which falls under the category of organohalogens. Its chemical formula is C7H13ClO2. 7-CHLOROHEPTANOIC ACID is also listed under different names such as Heptanoic acid and Enanthic acid. It's a chlorinated carboxylic acid and is relatively less common compared to other similar compounds. The chemical is mainly used in the synthesis of various pharmaceuticals but can also serve other industrial purposes. As with many chemicals, safety measures need to be followed while handling it due to its potentially hazardous properties.

InChI:InChI=1/C7H13ClO2/c8-6-4-2-1-3-5-7(9)10/h1-6H2,(H,9,10)

Upstream product

• 3993-94-0 1,1,7-trichloro-1-heptene 
• 7601-90-3 perchloric acid 
• 505-48-6 octane-1,8-dioic acid 
• 10297-06-0 1-chloro-5-hexyne 
• 6294-17-3 1-bromo-6-chlorohexane 
• 50592-87-5 1-bromo-6-methoxyhexane 
• 629-03-8 1 ,6-dibromohexane 
• 502-42-1 cycloheptanone 
• 95257-99-1 cycloheptanone hydroperoxide 
• 89856-94-0 7-Chlor-heptin-⁽²⁾-saeure 
• 124-38-9 carbon dioxide 
• 361541-51-7 (6-chlorohexyl)magnesium bromide 
• 3922-36-9 1,1,1,7-tetrachloroheptane 

Downstream Products

• 928-86-9 7-dimethylamino-heptanoic acid 
• 18093-32-8 6-phenyl-heptanoic acid amide 
• 1119-60-4 hept-6-enoic acid 
• 52000-32-5 7-mercaptoheptanoic acid 
• 55944-70-2 7-chloro-1-heptanol 
• 3922-28-9 1,12-dichlorododecane 
• 88019-89-0 7-iodoheptanoic acid 
• 51237-41-3 α,ω-dichlorooenanthic acid 
• 51237-40-2 2-bromo-7-chloroheptanoic acid 
• 54771-63-0 7-chloroheptanoic acid chloride 
• 2931-10-4 2-ethylcyclopent-2-en-1-one 
• 91343-34-9 7-Dimethylamino-oenanthsaeure-methylester 
• 30964-01-3 non-8-ynoic acid 
• 3710-42-7 7-hydroxyheptanoic acid 

Relevant articles and documents

Solid-state chlorodecarboxylation of mono- and dicarboxylic acids with the Pb(OAc)4-MCl system

Solid state reactions of acids RCOOH (R = n-C7H15, BuC(Et)H, n-C9H19, PhCH2, PhCH 2CH2, H2C=CH(CH2)8, or MeOOC(CH2)3) with Pb(OAc)4 combined with KCl, NaCl, CdCl2, or NH4Cl in the absence of a solvent and without mechanical activation afford chlorohydrocarbons RCl. The corresponding reactions of acids HOOC(CH2)nCOOH (n = 3-6) give dichloroalkanes Cl(CH2)nCl and γ-butyrolactone (n = 3).

A new approach to the synthesis of cilastatin, an inhibitor of renal dipeptidase

A convenient preoarative synthesis of cilastatin, an inhibitor of renal dipeptidase used in drugs with the antibiotic imipenem, has been elaborated.The key intermediate in this synthesis is 2-amino-7-chloroheptanoic acid prepared by oxidative cleavage of cycloheptanone followed by bromination of 7-chloroheptanoyl chloride with subsequent amination of the 2-bromo-7-chloroheptanoic acid thus formed.All of the stages of the new synthesis are easily performed, as is the isolation of the intermediate products, and they do not require any organometallic reagents. - Key words: cilastatin, (R)-cysteine, 7-chloroheptanoic acid, 2-amino-7-chloro-2-heptenoic acid, 2,2-dimethylcyclopropanecarbonyl chloride; oxidation, bromination, amination, cyclopropanation.