4-chlorobutyric acid 5-(4-chlorobutyrylamino)-2-[(2-methoxyethyl)methylamino]benzyl ester

Base Information

Chemical Name:4-chlorobutyric acid 5-(4-chlorobutyrylamino)-2-[(2-methoxyethyl)methylamino]benzyl ester
CAS No.:943513-32-4
Molecular Formula:C₁₉H₂₈Cl₂N₂O₄
Molecular Weight:419.348
Hs Code.:

Synonyms:4-chlorobutyric acid 5-(4-chlorobutyrylamino)-2-[(2-methoxyethyl)methylamino]benzyl ester

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Chemical Property of 4-chlorobutyric acid 5-(4-chlorobutyrylamino)-2-[(2-methoxyethyl)methylamino]benzyl ester

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Technology Process of 4-chlorobutyric acid 5-(4-chlorobutyrylamino)-2-[(2-methoxyethyl)methylamino]benzyl ester

There total 3 articles about 4-chlorobutyric acid 5-(4-chlorobutyrylamino)-2-[(2-methoxyethyl)methylamino]benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 943513-57-3
2-[(2-methoxyethyl)methylamino]-5-nitrobenzoic acid methyl ester

: 943513-32-4
4-chlorobutyric acid 5-(4-chlorobutyrylamino)-2-[(2-methoxyethyl)methylamino]benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / iron; NH₄Cl / tetrahydrofuran; methanol; H₂O / 3 h / 100 °C

2: 93 percent / LiAlH₄ / tetrahydrofuran / 7 h / 20 °C

3: 51 percent / AcONa; AcOH / tetrahydrofuran / 1.5 h / 20 °C

With lithium aluminium tetrahydride; sodium acetate; iron; ammonium chloride; acetic acid; In tetrahydrofuran; methanol; water;
DOI:10.1016/j.bmcl.2007.03.027

Reference yield:

: 943513-30-2
5-amino-2-[(2-methoxyethyl)methylamino]benzoic acid methyl ester

: 943513-32-4
4-chlorobutyric acid 5-(4-chlorobutyrylamino)-2-[(2-methoxyethyl)methylamino]benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / LiAlH₄ / tetrahydrofuran / 7 h / 20 °C

2: 51 percent / AcONa; AcOH / tetrahydrofuran / 1.5 h / 20 °C

With lithium aluminium tetrahydride; sodium acetate; acetic acid; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2007.03.027

Reference yield:

: 2965-22-2
methyl 2-fluoro-5-nitro-benzoate

: 943513-32-4
4-chlorobutyric acid 5-(4-chlorobutyrylamino)-2-[(2-methoxyethyl)methylamino]benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / K₂CO₃ / dimethylsulfoxide / 2 h / 20 °C

2: 100 percent / iron; NH₄Cl / tetrahydrofuran; methanol; H₂O / 3 h / 100 °C

3: 93 percent / LiAlH₄ / tetrahydrofuran / 7 h / 20 °C

4: 51 percent / AcONa; AcOH / tetrahydrofuran / 1.5 h / 20 °C

With lithium aluminium tetrahydride; sodium acetate; iron; potassium carbonate; ammonium chloride; acetic acid; In tetrahydrofuran; methanol; water; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2007.03.027