(E)-3-(5-chloro-2-tetrazol-1-ylphenyl)-N-(E)-(S)-8-oxa-16,18-diazatricyclo[13.2.1.0(2,7)]octadeca-1⁽¹⁷⁾,2,4,6,11,15⁽¹⁸⁾-hexaen-14-ylacrylamide trifluoroacetate

Base Information

• Chemical Name: (E)-3-(5-chloro-2-tetrazol-1-ylphenyl)-N-(E)-(S)-8-oxa-16,18-diazatricyclo[13.2.1.0(2,7)]octadeca-1⁽¹⁷⁾,2,4,6,11,15⁽¹⁸⁾-hexaen-14-ylacrylamide trifluoroacetate
• CAS No.: 1329159-46-7
• Molecular Formula: C₂HF₃O₂*C₂₅H₂₂ClN₇O₂
• Molecular Weight: 601.972

Synonyms:(E)-3-(5-chloro-2-tetrazol-1-ylphenyl)-N-(E)-(S)-8-oxa-16,18-diazatricyclo[13.2.1.0(2,7)]octadeca-1⁽¹⁷⁾,2,4,6,11,15⁽¹⁸⁾-hexaen-14-ylacrylamide trifluoroacetate

Chemical Property of (E)-3-(5-chloro-2-tetrazol-1-ylphenyl)-N-(E)-(S)-8-oxa-16,18-diazatricyclo[13.2.1.0(2,7)]octadeca-1⁽¹⁷⁾,2,4,6,11,15⁽¹⁸⁾-hexaen-14-ylacrylamide trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-3-(5-chloro-2-tetrazol-1-ylphenyl)-N-(E)-(S)-8-oxa-16,18-diazatricyclo[13.2.1.0(2,7)]octadeca-1⁽¹⁷⁾,2,4,6,11,15⁽¹⁸⁾-hexaen-14-ylacrylamide trifluoroacetate

There total 4 articles about (E)-3-(5-chloro-2-tetrazol-1-ylphenyl)-N-(E)-(S)-8-oxa-16,18-diazatricyclo[13.2.1.0(2,7)]octadeca-1⁽¹⁷⁾,2,4,6,11,15⁽¹⁸⁾-hexaen-14-ylacrylamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

2,5-dioxopyrrolidin-1-yl (2E)-3-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoate (1094107-15-9) + (E)-(S)-(8-oxa-16,18-diazatricyclo[13.2.1.0(2,7)]octadeca-1(17),2,4,6,11,15(18)-hexaen-14-yl)amine bis(trifluoroacetate) + trifluoroacetic acid (76-05-1) → (E)-3-(5-chloro-2-tetrazol-1-ylphenyl)-N-(E)-(S)-8-oxa-16,18-diazatricyclo[13.2.1.0(2,7)]octadeca-1(17),2,4,6,11,15(18)-hexaen-14-ylacrylamide trifluoroacetate (1329159-46-7)

Guidance literature:

2,5-dioxopyrrolidin-1-yl (2E)-3-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoate; (E)-(S)-(8-oxa-16,18-diazatricyclo[13.2.1.0(2,7)]octadeca-1⁽¹⁷⁾,2,4,6,11,15⁽¹⁸⁾-hexaen-14-yl)amine bis(trifluoroacetate); With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.75h;

trifluoroacetic acid; In water;

Reference yield:

[(E)-(S)-16-(2-trimethylsilanylethoxymethyl)-8-oxa-16,18-diazatricyclo[13.2.1.0(2,7)]octadeca-1(17),2,4,6,11,15(18)-hexaen-14-yl]carbamic acid tert-butyl ester trifluoroacetate (1329167-10-3) → (E)-3-(5-chloro-2-tetrazol-1-ylphenyl)-N-(E)-(S)-8-oxa-16,18-diazatricyclo[13.2.1.0(2,7)]octadeca-1(17),2,4,6,11,15(18)-hexaen-14-ylacrylamide trifluoroacetate (1329159-46-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride; water / ethanol / 50 °C

1.2: pH 10

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.75 h

With hydrogenchloride; water; N-ethyl-N,N-diisopropylamine; In ethanol; N,N-dimethyl-formamide;

Reference yield:

{(S)-1-[4-(2-but-3-enyloxyphenyl)-1H-imidazol-2-yl]but-3-enyl}carbamic acid tert-butyl ester (1329167-07-8) → (E)-3-(5-chloro-2-tetrazol-1-ylphenyl)-N-(E)-(S)-8-oxa-16,18-diazatricyclo[13.2.1.0(2,7)]octadeca-1(17),2,4,6,11,15(18)-hexaen-14-ylacrylamide trifluoroacetate (1329159-46-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

1.2: 0 - 20 °C

2.1: toluene-4-sulfonic acid / dichloromethane / 1.5 h / 40 °C / Inert atmosphere

2.2: 1 h

3.1: hydrogenchloride; water / ethanol / 50 °C

3.2: pH 10

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.75 h

With hydrogenchloride; water; sodium hydride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

2,5-dioxopyrrolidin-1-yl (2E)-3-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoate

trifluoroacetic acid

{(S)-1-[4-(2-but-3-enyloxyphenyl)-1H-imidazol-2-yl]but-3-enyl}carbamic acid tert-butyl ester

{(S)-1-[4-(2-but-3-enyloxyphenyl)-1-(2-trimethylsilanylethoxymethyl)-1H-imidazol-2-yl]but-3-enyl}carbamic acid tert-butyl ester

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