2,5-dioxopyrrolidin-1-yl (2E)-3-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoate

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Chemical Name:2,5-dioxopyrrolidin-1-yl (2E)-3-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoate
CAS No.:1094107-15-9
Molecular Formula:C₁₄H₁₀ClN₅O₄
Molecular Weight:347.717
Hs Code.:

Synonyms:2,5-dioxopyrrolidin-1-yl (2E)-3-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoate

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Chemical Property of 2,5-dioxopyrrolidin-1-yl (2E)-3-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoate

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Technology Process of 2,5-dioxopyrrolidin-1-yl (2E)-3-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoate

There total 3 articles about 2,5-dioxopyrrolidin-1-yl (2E)-3-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 942316-73-6
(2E)-3-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]-prop-2-enoic acid

: 1094107-15-9
2,5-dioxopyrrolidin-1-yl (2E)-3-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoate

Guidance literature:: With diisopropyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1021/acsmedchemlett.5b00066

Reference yield:

: 879016-22-5
5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)benzaldehyde

: 1094107-15-9
2,5-dioxopyrrolidin-1-yl (2E)-3-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.75 h / 0 - 20 °C / Inert atmosphere

1.2: 0.5 h / 20 °C / Inert atmosphere

2.1: sodium hydroxide / methanol / 2.5 h / 20 °C / Inert atmosphere

3.1: diisopropyl-carbodiimide / tetrahydrofuran; N,N-dimethyl-formamide / Inert atmosphere

With sodium hydride; sodium hydroxide; diisopropyl-carbodiimide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2016.03.062

Reference yield:

: 942316-72-5
methyl (2E)-3-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoate

: 1094107-15-9
2,5-dioxopyrrolidin-1-yl (2E)-3-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / methanol / 2.5 h / 20 °C / Inert atmosphere

2: diisopropyl-carbodiimide / tetrahydrofuran; N,N-dimethyl-formamide / Inert atmosphere

With sodium hydroxide; diisopropyl-carbodiimide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2016.03.062