N-(9-Fluorenylmethoxycarbonyl)-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1->3)-O-(2-acetamido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-serin-tert-butylester

Base Information

• Chemical Name: N-(9-Fluorenylmethoxycarbonyl)-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1->3)-O-(2-acetamido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-serin-tert-butylester
• CAS No.: 120204-23-1
• Molecular Formula: C₅₈H₆₄N₂O₂₁
• Molecular Weight: 1125.15
• Mol file: 120204-23-1.mol

Synonyms:N-(9-Fluorenylmethoxycarbonyl)-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1->3)-O-(2-acetamido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-serin-tert-butylester

Chemical Property of N-(9-Fluorenylmethoxycarbonyl)-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1->3)-O-(2-acetamido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-serin-tert-butylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(9-Fluorenylmethoxycarbonyl)-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1->3)-O-(2-acetamido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-serin-tert-butylester

There total 6 articles about N-(9-Fluorenylmethoxycarbonyl)-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1->3)-O-(2-acetamido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-serin-tert-butylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine (73724-45-5) → N-(9-Fluorenylmethoxycarbonyl)-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1->3)-O-(2-acetamido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-serin-tert-butylester (120204-23-1)

Guidance literature:

Multi-step reaction with 5 steps

1: NEt₃ / CH₂Cl₂ / 30 h

2: conc.H₂SO₄ / CH₂Cl₂ / 240 h

3: N₂H₄*H₂O / ethanol / 0.5 h

4: 1.) AgClO₄, molecular sieve / 1.) CH₂Cl₂, toluene, 1 h, -20 deg C; 2.) 2 d

5: 1.) H₂S; 2.) pyridine / 1.) pyridine, H₂O, 0 deg C, 3 h, room temp., 5 h; 2.) 0 deg C, 12 h

With pyridine; molecular sieve; sulfuric acid; hydrogen sulfide; silver perchlorate; hydrazine hydrate; triethylamine; In ethanol; dichloromethane;

Reference yield:

O-(Acetoacetyl)-N-(9-fluorenylmethoxycarbonyl)-L-serin (120791-74-4) → N-(9-Fluorenylmethoxycarbonyl)-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1->3)-O-(2-acetamido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-serin-tert-butylester (120204-23-1)

Guidance literature:

Multi-step reaction with 4 steps

1: conc.H₂SO₄ / CH₂Cl₂ / 240 h

2: N₂H₄*H₂O / ethanol / 0.5 h

3: 1.) AgClO₄, molecular sieve / 1.) CH₂Cl₂, toluene, 1 h, -20 deg C; 2.) 2 d

4: 1.) H₂S; 2.) pyridine / 1.) pyridine, H₂O, 0 deg C, 3 h, room temp., 5 h; 2.) 0 deg C, 12 h

With pyridine; molecular sieve; sulfuric acid; hydrogen sulfide; silver perchlorate; hydrazine hydrate; In ethanol; dichloromethane;

Reference yield:

O-(Acetoacetyl)-N-(9-fluorenylmethoxycarbonyl)-L-serin-tert-butylester (120792-31-6) → N-(9-Fluorenylmethoxycarbonyl)-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1->3)-O-(2-acetamido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-serin-tert-butylester (120204-23-1)

Guidance literature:

Multi-step reaction with 3 steps

1: N₂H₄*H₂O / ethanol / 0.5 h

2: 1.) AgClO₄, molecular sieve / 1.) CH₂Cl₂, toluene, 1 h, -20 deg C; 2.) 2 d

3: 1.) H₂S; 2.) pyridine / 1.) pyridine, H₂O, 0 deg C, 3 h, room temp., 5 h; 2.) 0 deg C, 12 h

With pyridine; molecular sieve; hydrogen sulfide; silver perchlorate; hydrazine hydrate; In ethanol;

upstream raw materials:

acetic anhydride

N-(9-Fluorenylmethoxycarbonyl)-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1->3)-O-(2-azido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-serin-tert-butylester

2-azido-4,6-di-O-benzoyl-2-deoxy-3-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-α-D-galactopyranosyl bromide

N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine