Technology Process of 3-(3-(4-ethylphenyl)imidazo[1,2-a]pyrazin-5-yl)quinoline
There total 5 articles about 3-(3-(4-ethylphenyl)imidazo[1,2-a]pyrazin-5-yl)quinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1,10-Phenanthroline; palladium diacetate; caesium carbonate;
In
N,N-dimethyl acetamide;
at 140 ℃;
for 27h;
Sealed tube;
Molecular sieve;
DOI:10.1002/ejoc.201301802
- Guidance literature:
-
Multi-step reaction with 2 steps
1: Trimethylacetic acid; palladium diacetate; tricyclohexylphosphine tetrafluoroborate; potassium carbonate / N,N-dimethyl-formamide / 100 °C / Inert atmosphere; Sealed tube
2: caesium carbonate; 1,10-Phenanthroline; palladium diacetate / N,N-dimethyl acetamide / 27 h / 140 °C / Sealed tube; Molecular sieve
With
1,10-Phenanthroline; palladium diacetate; potassium carbonate; caesium carbonate; tricyclohexylphosphine tetrafluoroborate; Trimethylacetic acid;
In
N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201301802
- Guidance literature:
-
Multi-step reaction with 2 steps
1: Trimethylacetic acid; palladium diacetate; tricyclohexylphosphine tetrafluoroborate; potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere
2: caesium carbonate; 1,10-Phenanthroline; palladium diacetate / N,N-dimethyl acetamide / 27 h / 140 °C / Sealed tube; Molecular sieve
With
1,10-Phenanthroline; palladium diacetate; potassium carbonate; caesium carbonate; tricyclohexylphosphine tetrafluoroborate; Trimethylacetic acid;
In
N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201301802
