N-(3,5-dimethyl-4'-phenoxybiphenyl-4-yl)-2,2,2-trifluoroacetamide

Base Information

• Chemical Name: N-(3,5-dimethyl-4'-phenoxybiphenyl-4-yl)-2,2,2-trifluoroacetamide
• CAS No.: 934273-82-2
• Molecular Formula: C₂₂H₁₈F₃NO₂
• Molecular Weight: 385.386
• Mol file: 934273-82-2.mol

Synonyms:N-(3,5-dimethyl-4'-phenoxybiphenyl-4-yl)-2,2,2-trifluoroacetamide

Chemical Property of N-(3,5-dimethyl-4'-phenoxybiphenyl-4-yl)-2,2,2-trifluoroacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3,5-dimethyl-4'-phenoxybiphenyl-4-yl)-2,2,2-trifluoroacetamide

There total 2 articles about N-(3,5-dimethyl-4'-phenoxybiphenyl-4-yl)-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(4-bromo-2,6-dimethylphenyl)-2,2,2-trifluoroacetamide (872415-94-6) + 4-phenoxyphenylboronic acid (51067-38-0) → N-(3,5-dimethyl-4'-phenoxybiphenyl-4-yl)-2,2,2-trifluoroacetamide (934273-82-2)

Guidance literature:

With sodium carbonate; palladium diacetate; In methanol; at 20 ℃; for 4h; sonication;

DOI:10.1016/j.tet.2007.01.023

Reference yield:

4-bromo-2,6-dimethylphenylamine (24596-19-8) → N-(3,5-dimethyl-4'-phenoxybiphenyl-4-yl)-2,2,2-trifluoroacetamide (934273-82-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate / diethyl ether / 0.75 h / 0 - 20 °C

2: sodium carbonate / palladium(II) acetate / methanol / 4 h / 20 °C / sonication

With sodium carbonate; palladium diacetate; In methanol; diethyl ether; 2: Suzuki-Miyaura cross coupling;

DOI:10.1016/j.tet.2007.01.023

Reference yield: 54.0%

N-(3,5-dimethyl-4'-phenoxybiphenyl-4-yl)-2,2,2-trifluoroacetamide (934273-82-2) → 3,5-dimethyl-4'-phenoxybiphenyl-4-amine (934273-86-6)

Guidance literature:

N-(3,5-dimethyl-4'-phenoxybiphenyl-4-yl)-2,2,2-trifluoroacetamide; With hydrogenchloride; for 17h; Heating;

With barium dihydroxide; In water; for 1.5h; Heating;

DOI:10.1016/j.tet.2007.01.023

upstream raw materials:

N-(4-bromo-2,6-dimethylphenyl)-2,2,2-trifluoroacetamide

4-phenoxyphenylboronic acid

4-bromo-2,6-dimethylphenylamine

Downstream raw materials:

3,5-dimethyl-4'-phenoxybiphenyl-4-amine