N²-[5-chloro-2-(4-chlorophenoxy)phenyl]-N²-{2-[2,3-dihydro-1H-inden-2-yl(methyl)amino]-2-oxoethyl}-N¹-(piperidin-2-ylmethyl)glycinamide hydrochloride

Base Information

• Chemical Name: N²-[5-chloro-2-(4-chlorophenoxy)phenyl]-N²-{2-[2,3-dihydro-1H-inden-2-yl(methyl)amino]-2-oxoethyl}-N¹-(piperidin-2-ylmethyl)glycinamide hydrochloride
• CAS No.: 1286264-33-2
• Molecular Formula: C₃₂H₃₆Cl₂N₄O₃*ClH
• Molecular Weight: 632.03

Synonyms:N²-[5-chloro-2-(4-chlorophenoxy)phenyl]-N²-{2-[2,3-dihydro-1H-inden-2-yl(methyl)amino]-2-oxoethyl}-N¹-(piperidin-2-ylmethyl)glycinamide hydrochloride

Chemical Property of N²-[5-chloro-2-(4-chlorophenoxy)phenyl]-N²-{2-[2,3-dihydro-1H-inden-2-yl(methyl)amino]-2-oxoethyl}-N¹-(piperidin-2-ylmethyl)glycinamide hydrochloride

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Technology Process of N²-[5-chloro-2-(4-chlorophenoxy)phenyl]-N²-{2-[2,3-dihydro-1H-inden-2-yl(methyl)amino]-2-oxoethyl}-N¹-(piperidin-2-ylmethyl)glycinamide hydrochloride

There total 11 articles about N²-[5-chloro-2-(4-chlorophenoxy)phenyl]-N²-{2-[2,3-dihydro-1H-inden-2-yl(methyl)amino]-2-oxoethyl}-N¹-(piperidin-2-ylmethyl)glycinamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C37H44Cl2N4O5 → N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-{2-[2,3-dihydro-1H-inden-2-yl(methyl)amino]-2-oxoethyl}-N1-(piperidin-2-ylmethyl)glycinamide hydrochloride (1286264-33-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃;

DOI:10.1016/j.bmc.2015.05.018

Reference yield:

N-methylindan-2-amine hydrochloride (10408-85-2) → N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-{2-[2,3-dihydro-1H-inden-2-yl(methyl)amino]-2-oxoethyl}-N1-(piperidin-2-ylmethyl)glycinamide hydrochloride (1286264-33-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 20 °C

1.2: 1 h / 0 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0 - 20 °C

3.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2015.05.018

Reference yield:

2-(4'-chlorophenoxy)-5-chloro-aniline (121-27-7) → N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-{2-[2,3-dihydro-1H-inden-2-yl(methyl)amino]-2-oxoethyl}-N1-(piperidin-2-ylmethyl)glycinamide hydrochloride (1286264-33-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / 5 h / 140 °C

2.1: sodium hydroxide; water / methanol; tetrahydrofuran / 2 h / 20 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 20 °C

3.2: 1 h / 0 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0 - 20 °C

5.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 20 °C

With hydrogenchloride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2015.05.018

upstream raw materials:

N-methylindan-2-amine hydrochloride

2,5-dichloronitrobenzene

4-chloro-phenol

2-(4'-chlorophenoxy)-5-chloro-aniline

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