121-27-7Relevant articles and documents
Preparation method of active bactericide 4,4'-dichloro-2-hydroxyl diphenyl ether
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Paragraph 0031; 0034; 0036, (2017/12/09)
The invention discloses a preparation method of an active bactericide 4,4'-dichloro-2-hydroxyl diphenyl ether. The preparation method comprises the following steps: preparing phenol metal salts from p-chlorophenol under the effect of an alkali solution; carrying out condensation reactions, nitro reduction reactions, and diazotization hydrolysis reactions between phenol metal salts and 2,5-dichloronitrobenzene; extracting the reaction product by a solvent; and purifying the extract by vacuum distillation to obtain the high quality active bactericide. The operation is convenient, the production cost is low, and the product purity is high. The bactericide can effectively kill or inhibit gram positive bacteria and gram negative bacteria. The bactericide can be easily compounded with a negative ion surfactant, a nonionic surfactant, an amphoteric surfactant, and a positive ion surfactant.
Computational and Experimental Studies of Phthaloyl Peroxide-Mediated Hydroxylation of Arenes Yield a More Reactive Derivative, 4,5-Dichlorophthaloyl Peroxide
Camelio, Andrew M.,Liang, Yong,Eliasen, Anders M.,Johnson, Trevor C.,Yuan, Changxia,Schuppe, Alex W.,Houk,Siegel, Dionicio
, p. 8084 - 8095 (2015/09/01)
The oxidation of arenes by the reagent phthaloyl peroxide provides a new method for the synthesis of phenols. A new, more reactive arene oxidizing reagent, 4,5-dichlorophthaloyl peroxide, computationally predicted and experimentally determined to possess enhanced reactivity, has expanded the scope of the reaction while maintaining a high level of tolerance for diverse functional groups. The reaction proceeds through a novel "reverse-rebound" mechanism with diradical intermediates. Mechanistic insight was achieved through isolation and characterization of minor byproducts, determination of linear free energy correlations, and computational analysis of substituent effects of arenes, each of which provided additional support for the reaction proceeding through the diradical pathway.
11-(1,2,3,6-Tetrahydro-substituted-4-pyridyl)-dibenz[b,f][1,4]oxazepines
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, (2008/06/13)
Unsubstituted, mono-, di- or trisubstituted-11-(1,2,3,6-tetrahydro-substituted-4-pyridyl)-dibenz[b,f][1,4]oxazepines, useful as anti-psychotic agents..