121-27-7Relevant articles and documents
Preparation method of active bactericide 4,4'-dichloro-2-hydroxyl diphenyl ether
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, (2017/12/09)
The invention discloses a preparation method of an active bactericide 4,4'-dichloro-2-hydroxyl diphenyl ether. The preparation method comprises the following steps: preparing phenol metal salts from p-chlorophenol under the effect of an alkali solution; carrying out condensation reactions, nitro reduction reactions, and diazotization hydrolysis reactions between phenol metal salts and 2,5-dichloronitrobenzene; extracting the reaction product by a solvent; and purifying the extract by vacuum distillation to obtain the high quality active bactericide. The operation is convenient, the production cost is low, and the product purity is high. The bactericide can effectively kill or inhibit gram positive bacteria and gram negative bacteria. The bactericide can be easily compounded with a negative ion surfactant, a nonionic surfactant, an amphoteric surfactant, and a positive ion surfactant.
Discovery and structural analyses of S-adenosyl-l-homocysteine hydrolase inhibitors based on non-adenosine analogs
Nakao, Akira,Suzuki, Hiroko,Ueno, Hiroaki,Iwasaki, Hiroshi,Setsuta, Tomofumi,Kashima, Akiko,Sunada, Shinji
, p. 4952 - 4969 (2015/08/03)
Optimization of a new series of S-adenosyl-l-homocysteine hydrolase (AdoHcyase) inhibitors based on non-adenosine analogs led to very potent compounds 14n, 18a, and 18b with IC50 values of 13 ± 3, 5.0 ± 2.0, and 8.5 ± 3.1 nM, respectively. An X-ray crystal structure of AdoHcyase with NAD+ and 18a showed a novel open form co-crystal structure. 18a in the co-crystals formed intramolecular eight membered ring hydrogen bond formations. A single crystal X-ray structure of 14n also showed an intramolecular eight-membered ring hydrogen bond interaction.
11-(1,2,3,6-Tetrahydro-substituted-4-pyridyl)-dibenz[b,f][1,4]oxazepines
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, (2008/06/13)
Unsubstituted, mono-, di- or trisubstituted-11-(1,2,3,6-tetrahydro-substituted-4-pyridyl)-dibenz[b,f][1,4]oxazepines, useful as anti-psychotic agents..