N-(2-(5-methylfuran-2-yl)-2-phenylethyl)-N-tosylprop-2-yn-1-amine

Base Information

• Chemical Name: N-(2-(5-methylfuran-2-yl)-2-phenylethyl)-N-tosylprop-2-yn-1-amine
• CAS No.: 1403651-10-4
• Molecular Formula: C₂₃H₂₃NO₃S
• Molecular Weight: 393.507
• Mol file: 1403651-10-4.mol

Synonyms:N-(2-(5-methylfuran-2-yl)-2-phenylethyl)-N-tosylprop-2-yn-1-amine

Chemical Property of N-(2-(5-methylfuran-2-yl)-2-phenylethyl)-N-tosylprop-2-yn-1-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-(5-methylfuran-2-yl)-2-phenylethyl)-N-tosylprop-2-yn-1-amine

There total 5 articles about N-(2-(5-methylfuran-2-yl)-2-phenylethyl)-N-tosylprop-2-yn-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-methyl-N-[2-(5-methylfuran-2-yl)-2-phenylethyl]benzenesulfonamide + propargyl bromide (106-96-7) → N-(2-(5-methylfuran-2-yl)-2-phenylethyl)-N-tosylprop-2-yn-1-amine (1403651-10-4)

Guidance literature:

With caesium carbonate; In acetone; at 20 ℃; for 24h;

DOI:10.1002/chem.201200306

Reference yield:

2-(5-methylfuran-2-yl)-2-phenyl-ethylamine (1403651-47-7) → N-(2-(5-methylfuran-2-yl)-2-phenylethyl)-N-tosylprop-2-yn-1-amine (1403651-10-4)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 36 h / 20 °C

2: caesium carbonate / acetone / 24 h / 20 °C

With caesium carbonate; triethylamine; In dichloromethane; acetone;

DOI:10.1002/chem.201200306

Reference yield:

benzaldehyde (100-52-7) → N-(2-(5-methylfuran-2-yl)-2-phenylethyl)-N-tosylprop-2-yn-1-amine (1403651-10-4)

Guidance literature:

Multi-step reaction with 5 steps

1: ammonium acetate / 5 h / Reflux

2: zinc(II) iodide / 72 h / 20 °C / Inert atmosphere

3: lithium aluminium tetrahydride / diethyl ether / 16 h / 20 °C / Inert atmosphere

4: triethylamine / dichloromethane / 36 h / 20 °C

5: caesium carbonate / acetone / 24 h / 20 °C

With lithium aluminium tetrahydride; ammonium acetate; caesium carbonate; triethylamine; zinc(II) iodide; In diethyl ether; dichloromethane; acetone;

DOI:10.1002/chem.201200306

upstream raw materials:

benzaldehyde

(2-nitroethenyl)benzene

2-methyl-5-(2-nitro-1-phenyl-ethyl)furan

2-(5-methylfuran-2-yl)-2-phenyl-ethylamine

Downstream raw materials:

1,2,3,4-tetrahydro-7-methyl-4-phenyl-2-tosylisoquinolin-8-ol