methyl 2-(6-{(3E)(6S,1R,2R)-2-methoxy-7-[(4-methoxyphenyl)methoxy]-1,4-dimethyl-6-(tert-butyldimethylsilyloxy)hept-3-enyl}(2S,4S,5S,6S)-2-methoxy-5-methyl-4-(tert-butyldimethylsiloxy)-2H-3,4,5,6-tetrahydropyran-2-yl)acetate

Base Information

Chemical Name:methyl 2-(6-{(3E)(6S,1R,2R)-2-methoxy-7-[(4-methoxyphenyl)methoxy]-1,4-dimethyl-6-(tert-butyldimethylsilyloxy)hept-3-enyl}(2S,4S,5S,6S)-2-methoxy-5-methyl-4-(tert-butyldimethylsiloxy)-2H-3,4,5,6-tetrahydropyran-2-yl)acetate
CAS No.:439143-46-1
Molecular Formula:C₄₀H₇₂O₉Si₂
Molecular Weight:753.177
Hs Code.:

methyl 2-(6-{(3E)(6S,1R,2R)-2-methoxy-7-[(4-methoxyphenyl)methoxy]-1,4-dimethyl-6-(tert-butyldimethylsilyloxy)hept-3-enyl}(2S,4S,5S,6S)-2-methoxy-5-methyl-4-(tert-butyldimethylsiloxy)-2H-3,4,5,6-tetrahydropyran-2-yl)acetate

Synonyms:methyl 2-(6-{(3E)(6S,1R,2R)-2-methoxy-7-[(4-methoxyphenyl)methoxy]-1,4-dimethyl-6-(tert-butyldimethylsilyloxy)hept-3-enyl}(2S,4S,5S,6S)-2-methoxy-5-methyl-4-(tert-butyldimethylsiloxy)-2H-3,4,5,6-tetrahydropyran-2-yl)acetate

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Chemical Property of methyl 2-(6-{(3E)(6S,1R,2R)-2-methoxy-7-[(4-methoxyphenyl)methoxy]-1,4-dimethyl-6-(tert-butyldimethylsilyloxy)hept-3-enyl}(2S,4S,5S,6S)-2-methoxy-5-methyl-4-(tert-butyldimethylsiloxy)-2H-3,4,5,6-tetrahydropyran-2-yl)acetate

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Technology Process of methyl 2-(6-{(3E)(6S,1R,2R)-2-methoxy-7-[(4-methoxyphenyl)methoxy]-1,4-dimethyl-6-(tert-butyldimethylsilyloxy)hept-3-enyl}(2S,4S,5S,6S)-2-methoxy-5-methyl-4-(tert-butyldimethylsiloxy)-2H-3,4,5,6-tetrahydropyran-2-yl)acetate

There total 12 articles about methyl 2-(6-{(3E)(6S,1R,2R)-2-methoxy-7-[(4-methoxyphenyl)methoxy]-1,4-dimethyl-6-(tert-butyldimethylsilyloxy)hept-3-enyl}(2S,4S,5S,6S)-2-methoxy-5-methyl-4-(tert-butyldimethylsiloxy)-2H-3,4,5,6-tetrahydropyran-2-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 333-27-7
methyl trifluoromethanesulfonate

: {(2S,4S,5S,6S)-4-(tert-Butyl-dimethyl-silanyloxy)-6-[(E)-(1R,2R,6S)-6-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-7-(4-methoxy-benzyloxy)-1,4-dimethyl-hept-3-enyl]-2-methoxy-5-methyl-tetrahydro-pyran-2-yl}-acetic acid methyl ester

: 439143-46-1
methyl 2-(6-{(3E)(6S,1R,2R)-2-methoxy-7-[(4-methoxyphenyl)methoxy]-1,4-dimethyl-6-(tert-butyldimethylsilyloxy)hept-3-enyl}(2S,4S,5S,6S)-2-methoxy-5-methyl-4-(tert-butyldimethylsiloxy)-2H-3,4,5,6-tetrahydropyran-2-yl)acetate

Guidance literature:: With 2,6-di-tert-butyl-pyridine; In dichloromethane; at 20 ℃;
DOI:10.1021/ja026235n

Reference yield:

: 101712-01-0
(S)-1-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-2-methylpentane-1,3-dione

: 439143-46-1
methyl 2-(6-{(3E)(6S,1R,2R)-2-methoxy-7-[(4-methoxyphenyl)methoxy]-1,4-dimethyl-6-(tert-butyldimethylsilyloxy)hept-3-enyl}(2S,4S,5S,6S)-2-methoxy-5-methyl-4-(tert-butyldimethylsiloxy)-2H-3,4,5,6-tetrahydropyran-2-yl)acetate

Guidance literature:: Multi-step reaction with 10 steps

1.1: Cy₂BCl; Et₃NMe₂ / diethyl ether / 0 °C

1.2: diethyl ether / -78 - -20 °C

2.1: Me₄NBH(OAc)3; AcOH / acetonitrile / 0 °C

3.1: HN(CH₂CH₂OH)2 / ethyl acetate / 20 °C

4.1: AlMe₃ / CH₂Cl₂ / 0 - 20 °C

5.1: PPTS / acetone / 20 °C

6.1: LiAlH₄ / diethyl ether / 20 °C

7.1: BF₃*OEt₂ / toluene / -90 °C

8.1: 2,6-lutidine / CH₂Cl₂ / -78 °C

9.1: PPTS / 20 °C

10.1: 2,6-di-tert-butylpyridine / CH₂Cl₂ / 20 °C

With 2,6-dimethylpyridine; lithium aluminium tetrahydride; 2,6-di-tert-butyl-pyridine; boron trifluoride diethyl etherate; dicyclohexylboron chloride; trimethylaluminum; pyridinium p-toluenesulfonate; acetic acid; 2,2'-iminobis[ethanol]; tetramethylammonium triacetoxyborohydride; In diethyl ether; dichloromethane; ethyl acetate; acetone; toluene; acetonitrile;
DOI:10.1021/ja026235n

Reference yield:

: 439143-54-1
(2E)(5S)-6-[(4-methoxyphenyl)methoxy]-3-methyl-5-(tert-butyldimethylsilyloxy)hex-2-enal

: 439143-46-1
methyl 2-(6-{(3E)(6S,1R,2R)-2-methoxy-7-[(4-methoxyphenyl)methoxy]-1,4-dimethyl-6-(tert-butyldimethylsilyloxy)hept-3-enyl}(2S,4S,5S,6S)-2-methoxy-5-methyl-4-(tert-butyldimethylsiloxy)-2H-3,4,5,6-tetrahydropyran-2-yl)acetate

Guidance literature:: Multi-step reaction with 10 steps

1.1: Cy₂BCl; Et₃NMe₂ / diethyl ether / 0 °C

1.2: diethyl ether / -78 - -20 °C

2.1: Me₄NBH(OAc)3; AcOH / acetonitrile / 0 °C

3.1: HN(CH₂CH₂OH)2 / ethyl acetate / 20 °C

4.1: AlMe₃ / CH₂Cl₂ / 0 - 20 °C

5.1: PPTS / acetone / 20 °C

6.1: LiAlH₄ / diethyl ether / 20 °C

7.1: BF₃*OEt₂ / toluene / -90 °C

8.1: 2,6-lutidine / CH₂Cl₂ / -78 °C

9.1: PPTS / 20 °C

10.1: 2,6-di-tert-butylpyridine / CH₂Cl₂ / 20 °C

With 2,6-dimethylpyridine; lithium aluminium tetrahydride; 2,6-di-tert-butyl-pyridine; boron trifluoride diethyl etherate; dicyclohexylboron chloride; trimethylaluminum; pyridinium p-toluenesulfonate; acetic acid; 2,2'-iminobis[ethanol]; tetramethylammonium triacetoxyborohydride; In diethyl ether; dichloromethane; ethyl acetate; acetone; toluene; acetonitrile;
DOI:10.1021/ja026235n