2-(α-Hydroxybenzyl)-5-benzyloxybenzaldehyde dimethylacetal

Base Information

Chemical Name:2-(α-Hydroxybenzyl)-5-benzyloxybenzaldehyde dimethylacetal
CAS No.:145127-88-4
Molecular Formula:C₂₃H₂₄O₄
Molecular Weight:364.441
Hs Code.:

Synonyms:2-(α-Hydroxybenzyl)-5-benzyloxybenzaldehyde dimethylacetal

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Chemical Property of 2-(α-Hydroxybenzyl)-5-benzyloxybenzaldehyde dimethylacetal

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Technology Process of 2-(α-Hydroxybenzyl)-5-benzyloxybenzaldehyde dimethylacetal

There total 2 articles about 2-(α-Hydroxybenzyl)-5-benzyloxybenzaldehyde dimethylacetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 498-60-2
furan-3-carboxaldehyde

: 81418-49-7
5-(benzyloxy)-2-bromobenzaldehyde dimethylacetal

: 145127-88-4
2-(α-Hydroxybenzyl)-5-benzyloxybenzaldehyde dimethylacetal

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane;

Reference yield:

: 81418-49-7
5-(benzyloxy)-2-bromobenzaldehyde dimethylacetal

: 100-52-7
benzaldehyde

: 145127-88-4
2-(α-Hydroxybenzyl)-5-benzyloxybenzaldehyde dimethylacetal

Guidance literature:: With n-butyllithium; Multistep reaction; 1.) THF, hexane, -70 deg C, 15 min, 2.) THF, hexane, from -70 to 10 deg C;
DOI:10.1021/jm960301c

Reference yield:

: 145127-88-4
2-(α-Hydroxybenzyl)-5-benzyloxybenzaldehyde dimethylacetal

: 145127-77-1
7-Hydroxy-3-methyl-4-phenyl-3H-naphtho[2,3-c]furan-1-one

Guidance literature:: Multi-step reaction with 11 steps

1: camphorsulfonic acid / toluene / 24 h / Heating

2: 29 percent / LiAlH₄ / tetrahydrofuran / 2.5 h / Heating

3: 73 percent / imidazole / tetrahydrofuran / 1 h / Ambient temperature

4: 92 percent / pyridinium chlorochromate, molecular sieves / CH₂Cl₂ / 1 h / Ambient temperature

5: 98 percent / tetrahydrofuran / 0.17 h / -78 °C

6: pyridine, 4-(dimethylamino)pyridine / 2 h / Ambient temperature

7: Bu₄NF, acetic acid / tetrahydrofuran / 2 h / 0 °C

8: 91 percent / KMnO₄, aq. phoshate buffer / 2-methyl-propan-2-ol; H₂O / 3 h / Ambient temperature

9: 100 percent / MeONa / methanol / 24 h / Ambient temperature

10: 100 percent / 6N aq. HCl / ethyl acetate / 0.33 h / Ambient temperature

11: 83 percent / H₂ / 10percent Pd/C / ethyl acetate / 48 h / Ambient temperature

With pyridine; 1H-imidazole; hydrogenchloride; dmap; potassium permanganate; lithium aluminium tetrahydride; molecular sieve; phoshate buffer; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; hydrogen; sodium methylate; acetic acid; pyridinium chlorochromate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; toluene; tert-butyl alcohol;
DOI:10.1021/jm960301c