3-(3-bromo-4-(3-fluoroazetidin-3-yl)phenyl)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole

Base Information

Chemical Name:3-(3-bromo-4-(3-fluoroazetidin-3-yl)phenyl)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole
CAS No.:1357614-75-5
Molecular Formula:C₁₉H₁₂BrCl₃F₄N₂O
Molecular Weight:546.574
Hs Code.:

Synonyms:3-(3-bromo-4-(3-fluoroazetidin-3-yl)phenyl)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole

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Chemical Property of 3-(3-bromo-4-(3-fluoroazetidin-3-yl)phenyl)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole

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Technology Process of 3-(3-bromo-4-(3-fluoroazetidin-3-yl)phenyl)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole

There total 9 articles about 3-(3-bromo-4-(3-fluoroazetidin-3-yl)phenyl)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1357614-74-4
3-(4-(1-benzhydryl-3-fluoroazetidin-3-yl)-3-bromophenyl)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole

: 1357614-75-5
3-(3-bromo-4-(3-fluoroazetidin-3-yl)phenyl)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole

Guidance literature:: With carbonochloridic acid 1-chloro-ethyl ester; In dichloromethane; acetonitrile; at 0 ℃; for 21h; Reflux;

Reference yield:

: 249647-24-3
3-bromo-4-iodobenzoic acid methyl ester

: 1357614-75-5
3-(3-bromo-4-(3-fluoroazetidin-3-yl)phenyl)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole

Guidance literature:: Multi-step reaction with 8 steps

1.1: diisobutylaluminium hydride / dichloromethane / 0.75 h / -78 °C / Inert atmosphere

2.1: sodium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite; sodium hydrogencarbonate / dichloromethane; water / 0 - 20 °C

2.2: 0.17 h

3.1: hydroxylamine hydrochloride / ethanol; water / 19 h / 20 - 50 °C

4.1: N-chloro-succinimide / N,N-dimethyl-formamide / 18 h / 20 °C

5.1: potassium hydrogencarbonate / ethyl acetate / 48 h / 20 °C

6.1: isopropylmagnesium chloride / tetrahydrofuran / 1.5 h / -40 °C / Inert atmosphere

6.2: 2.5 h / -40 - 20 °C

7.1: ethanaminium,N-(difluoro-λ⁴-sulfanylidene)-N-ethyl-,tetrafluoroborate; triethylamine; triethylamine tris(hydrogen fluoride) / dichloromethane / 2 h / -78 - 20 °C

8.1: carbonochloridic acid 1-chloro-ethyl ester / dichloromethane; acetonitrile / 21 h / 0 °C / Reflux

With sodium hypochlorite; N-chloro-succinimide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; carbonochloridic acid 1-chloro-ethyl ester; hydroxylamine hydrochloride; isopropylmagnesium chloride; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium hydrogencarbonate; triethylamine tris(hydrogen fluoride); triethylamine; ethanaminium,N-(difluoro-λ⁴-sulfanylidene)-N-ethyl-,tetrafluoroborate; sodium bromide; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 249647-26-5
(3-bromo-4-iodophenyl)methanol

: 1357614-75-5
3-(3-bromo-4-(3-fluoroazetidin-3-yl)phenyl)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite; sodium hydrogencarbonate / dichloromethane; water / 0 - 20 °C

1.2: 0.17 h

2.1: hydroxylamine hydrochloride / ethanol; water / 19 h / 20 - 50 °C

3.1: N-chloro-succinimide / N,N-dimethyl-formamide / 18 h / 20 °C

4.1: potassium hydrogencarbonate / ethyl acetate / 48 h / 20 °C

5.1: isopropylmagnesium chloride / tetrahydrofuran / 1.5 h / -40 °C / Inert atmosphere

5.2: 2.5 h / -40 - 20 °C

6.1: ethanaminium,N-(difluoro-λ⁴-sulfanylidene)-N-ethyl-,tetrafluoroborate; triethylamine; triethylamine tris(hydrogen fluoride) / dichloromethane / 2 h / -78 - 20 °C

7.1: carbonochloridic acid 1-chloro-ethyl ester / dichloromethane; acetonitrile / 21 h / 0 °C / Reflux

With sodium hypochlorite; N-chloro-succinimide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; carbonochloridic acid 1-chloro-ethyl ester; hydroxylamine hydrochloride; isopropylmagnesium chloride; sodium hydrogencarbonate; potassium hydrogencarbonate; triethylamine tris(hydrogen fluoride); triethylamine; ethanaminium,N-(difluoro-λ⁴-sulfanylidene)-N-ethyl-,tetrafluoroborate; sodium bromide; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;